Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C
The anti-hyperglycaemic effects of the leaves of Acer pycnanthum K. Koch, and the purification and identification of the active compounds were investigated. Extracts of the leaves showed a potent inhibitory effect on the α-glucosidase in both in vivo and in vitro experiments. The fractionation of th...
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| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2011-04, Vol.26 (2), p.176-180 |
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| container_title | Journal of enzyme inhibition and medicinal chemistry |
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| creator | Honma, Atsushi Koyama, Tomoyuki Yazawa, Kazunaga |
| description | The anti-hyperglycaemic effects of the leaves of Acer pycnanthum K. Koch, and the purification and identification of the active compounds were investigated. Extracts of the leaves showed a potent inhibitory effect on the α-glucosidase in both in vivo and in vitro experiments. The fractionation of the crude extract gave two active compounds, ginnalin B (6-O-galloyl-1,5-anhydro-D-glucitol) and ginnalin C (2-O-galloyl-1,5-anhydro-D-glucitol), by spectroscopic analysis. This is the first report that A. pycnanthum and its constituents may be useful for the prevention or treatment of diabetes mellitus. |
| doi_str_mv | 10.3109/14756366.2010.486795 |
| format | Article |
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This is the first report that A. pycnanthum and its constituents may be useful for the prevention or treatment of diabetes mellitus.</description><identifier>ISSN: 1475-6366</identifier><identifier>EISSN: 1475-6374</identifier><identifier>DOI: 10.3109/14756366.2010.486795</identifier><identifier>PMID: 20560858</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Acer - chemistry ; Acer pycnanthum ; Animals ; diabetes mellitus ; Enzyme Activation - drug effects ; Enzyme Inhibitors - pharmacology ; ginnalin B ; ginnalin C ; Hypoglycemic Agents - pharmacology ; Kinetics ; Male ; Mice ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Sorbitol - analogs & derivatives ; Sorbitol - chemistry ; Sorbitol - pharmacology ; Sucrase - antagonists & inhibitors ; α-glucosidase inhibitory effect</subject><ispartof>Journal of enzyme inhibition and medicinal chemistry, 2011-04, Vol.26 (2), p.176-180</ispartof><rights>2011 Informa UK, Ltd. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-da3cad5f88c6774dc60abad63f5fcc8f61e1825a11b90569d99e349f96b398a3</citedby><cites>FETCH-LOGICAL-c529t-da3cad5f88c6774dc60abad63f5fcc8f61e1825a11b90569d99e349f96b398a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20560858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Honma, Atsushi</creatorcontrib><creatorcontrib>Koyama, Tomoyuki</creatorcontrib><creatorcontrib>Yazawa, Kazunaga</creatorcontrib><title>Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C</title><title>Journal of enzyme inhibition and medicinal chemistry</title><addtitle>J Enzyme Inhib Med Chem</addtitle><description>The anti-hyperglycaemic effects of the leaves of Acer pycnanthum K. Koch, and the purification and identification of the active compounds were investigated. Extracts of the leaves showed a potent inhibitory effect on the α-glucosidase in both in vivo and in vitro experiments. The fractionation of the crude extract gave two active compounds, ginnalin B (6-O-galloyl-1,5-anhydro-D-glucitol) and ginnalin C (2-O-galloyl-1,5-anhydro-D-glucitol), by spectroscopic analysis. This is the first report that A. pycnanthum and its constituents may be useful for the prevention or treatment of diabetes mellitus.</description><subject>Acer - chemistry</subject><subject>Acer pycnanthum</subject><subject>Animals</subject><subject>diabetes mellitus</subject><subject>Enzyme Activation - drug effects</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>ginnalin B</subject><subject>ginnalin C</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Mice</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Sorbitol - analogs & derivatives</subject><subject>Sorbitol - chemistry</subject><subject>Sorbitol - pharmacology</subject><subject>Sucrase - antagonists & inhibitors</subject><subject>α-glucosidase inhibitory effect</subject><issn>1475-6366</issn><issn>1475-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQhSMEoqXtP0DIN04pdhI79gW0rEoLqsSld2vWGTeuHCfYjlD-fRO2rcSlJ49H772Z-YriI6OXNaPqC2taLmohLiu6thopWsXfFKdbuxR127x9qYU4KT6k9EBpxSrWvC9OKsoFlVyeFtMuZFf2y4Tx3i8GcHCGoLVociKjJblH8gsmCJiQROzIAJNHsjMYybSYACH380AgdMStDjOGlF2eMayfzXvvQgDvQiLf_4n258U7Cz7hxdN7Vtz9uLrb35S3v69_7ne3peGVymUHtYGOWymNaNumM4LCATpRW26NkVYwZLLiwNhBrceoTimsG2WVONRKQn1WfD7GTnH8M2PKenDJoPfrJeOctORtIxmnbFU2R6WJY0oRrZ6iGyAumlG9kdbPpPVGWh9Jr7ZPTwPmw4Ddi-kZ7Sr4dhS4YMc4wN8x-k5nWPwYbYRgXNriXx3x9b-EHsHn3kBE_TDOceWaXt_xEZ9Boe8</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Honma, Atsushi</creator><creator>Koyama, Tomoyuki</creator><creator>Yazawa, Kazunaga</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C</title><author>Honma, Atsushi ; Koyama, Tomoyuki ; Yazawa, Kazunaga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-da3cad5f88c6774dc60abad63f5fcc8f61e1825a11b90569d99e349f96b398a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acer - chemistry</topic><topic>Acer pycnanthum</topic><topic>Animals</topic><topic>diabetes mellitus</topic><topic>Enzyme Activation - drug effects</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>ginnalin B</topic><topic>ginnalin C</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Mice</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Sorbitol - analogs & derivatives</topic><topic>Sorbitol - chemistry</topic><topic>Sorbitol - pharmacology</topic><topic>Sucrase - antagonists & inhibitors</topic><topic>α-glucosidase inhibitory effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Honma, Atsushi</creatorcontrib><creatorcontrib>Koyama, Tomoyuki</creatorcontrib><creatorcontrib>Yazawa, Kazunaga</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Honma, Atsushi</au><au>Koyama, Tomoyuki</au><au>Yazawa, Kazunaga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C</atitle><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle><addtitle>J Enzyme Inhib Med Chem</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>26</volume><issue>2</issue><spage>176</spage><epage>180</epage><pages>176-180</pages><issn>1475-6366</issn><eissn>1475-6374</eissn><abstract>The anti-hyperglycaemic effects of the leaves of Acer pycnanthum K. Koch, and the purification and identification of the active compounds were investigated. Extracts of the leaves showed a potent inhibitory effect on the α-glucosidase in both in vivo and in vitro experiments. The fractionation of the crude extract gave two active compounds, ginnalin B (6-O-galloyl-1,5-anhydro-D-glucitol) and ginnalin C (2-O-galloyl-1,5-anhydro-D-glucitol), by spectroscopic analysis. This is the first report that A. pycnanthum and its constituents may be useful for the prevention or treatment of diabetes mellitus.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>20560858</pmid><doi>10.3109/14756366.2010.486795</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of enzyme inhibition and medicinal chemistry, 2011-04, Vol.26 (2), p.176-180 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acer - chemistry Acer pycnanthum Animals diabetes mellitus Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology ginnalin B ginnalin C Hypoglycemic Agents - pharmacology Kinetics Male Mice Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Sorbitol - analogs & derivatives Sorbitol - chemistry Sorbitol - pharmacology Sucrase - antagonists & inhibitors α-glucosidase inhibitory effect |
| title | Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C |
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