Autonomic receptor functions of the human ureter: an in vitro study

The autonomic receptor functions of ureteral smooth muscle were studied in vitro on strips of human ureter obtained at surgery. A dose-dependent, reproducible, contraction response to 5-hydroxytryptamine (Serotonin, 5-HT) was demonstrated. This response could be blocked by methysergide. Responses to...

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Veröffentlicht in:	Scandinavian journal of urology and nephrology 1978, Vol.12 (1), p.23
Hauptverfasser:	Long, S, Nergårdh, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adolescent Adult Autonomic Nervous System - drug effects Child Child, Preschool Humans Infant Muscle Contraction - drug effects Muscle, Smooth - innervation Receptors, Adrenergic, alpha - drug effects Receptors, Cholinergic - drug effects Receptors, Neurotransmitter - drug effects Receptors, Serotonin - drug effects Serotonin - pharmacology Ureter - innervation
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Zusammenfassung:	The autonomic receptor functions of ureteral smooth muscle were studied in vitro on strips of human ureter obtained at surgery. A dose-dependent, reproducible, contraction response to 5-hydroxytryptamine (Serotonin, 5-HT) was demonstrated. This response could be blocked by methysergide. Responses to acetylcholine and to drugs stimulating adrenergic receptor functions were also found, but they were weak and inconsistent. This suggests that contraction of ureteral smooth muscle is mediated through receptors which are sensitive to 5-hydroxytryptamine.
ISSN:	0036-5599