Peptide quantitation with methyl iodide isotopic tags and mass spectrometry

A novel method is presented for the quantitation of peptides based on their methylation by in vacuo chemical reaction with methyl iodide. Samples of two small peptides, hexaglycine and pentaalanine, were labeled with CH 3 I and CD 3 I, representing the "unknown" and "standard" re...

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Veröffentlicht in:	Analyst (London) 2010-06, Vol.135 (6), p.1456-146
Hauptverfasser:	Blagojevic, Voislav, Zhidkov, Nickholas, Tharmaratnam, Samuel, Pham, Van Thong, Kaplan, Harvey, Bohme, Diethard K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Chemical reactions Chemistry Deuterium Exchange Measurement Exact sciences and technology Hydrocarbons, Iodinated - chemistry Iodides Isotope Labeling Labels Mass spectrometers Mass spectrometry Methylation Peptides Peptides - analysis Spectrometric and optical methods Spectrometry, Mass, Electrospray Ionization - methods
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