Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naïve Subjects
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2010-08, Vol.54 (8), p.3170-3178 |
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| creator | MOYLE, Graeme BOFFITO, Marta NGUYEN, Tranh ONG, Voon YEH, Li-Tain QUART, Barry STOEHR, Albrecht RIEGER, Armin SHEN, Zancong MANHARD, Kimberly SHEEDY, Beth HINGORANI, Vijay RANEY, Anneke NGUYEN, Mai |
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| doi_str_mv | 10.1128/AAC.00268-10 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00268-10</identifier><identifier>PMID: 20498326</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adult ; Anti-HIV Agents - administration & dosage ; Anti-HIV Agents - adverse effects ; Anti-HIV Agents - pharmacokinetics ; Anti-HIV Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Double-Blind Method ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV-1 - drug effects ; HIV-1 - physiology ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Pharmacology ; Pharmacology. Drug treatments ; Reverse Transcriptase Inhibitors - administration & dosage ; Reverse Transcriptase Inhibitors - adverse effects ; Reverse Transcriptase Inhibitors - pharmacokinetics ; Reverse Transcriptase Inhibitors - therapeutic use ; RNA, Viral - blood ; Treatment Outcome ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Young Adult</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2010-08, Vol.54 (8), p.3170-3178</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010, American Society for Microbiology 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916334/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916334/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23059523$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20498326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOYLE, Graeme</creatorcontrib><creatorcontrib>BOFFITO, Marta</creatorcontrib><creatorcontrib>NGUYEN, Tranh</creatorcontrib><creatorcontrib>ONG, Voon</creatorcontrib><creatorcontrib>YEH, Li-Tain</creatorcontrib><creatorcontrib>QUART, Barry</creatorcontrib><creatorcontrib>STOEHR, Albrecht</creatorcontrib><creatorcontrib>RIEGER, Armin</creatorcontrib><creatorcontrib>SHEN, Zancong</creatorcontrib><creatorcontrib>MANHARD, Kimberly</creatorcontrib><creatorcontrib>SHEEDY, Beth</creatorcontrib><creatorcontrib>HINGORANI, Vijay</creatorcontrib><creatorcontrib>RANEY, Anneke</creatorcontrib><creatorcontrib>NGUYEN, Mai</creatorcontrib><title>Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naïve Subjects</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Adult</subject><subject>Anti-HIV Agents - administration & dosage</subject><subject>Anti-HIV Agents - adverse effects</subject><subject>Anti-HIV Agents - pharmacokinetics</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Reverse Transcriptase Inhibitors - administration & dosage</topic><topic>Reverse Transcriptase Inhibitors - adverse effects</topic><topic>Reverse Transcriptase Inhibitors - pharmacokinetics</topic><topic>Reverse Transcriptase Inhibitors - therapeutic use</topic><topic>RNA, Viral - blood</topic><topic>Treatment Outcome</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOYLE, Graeme</creatorcontrib><creatorcontrib>BOFFITO, Marta</creatorcontrib><creatorcontrib>NGUYEN, Tranh</creatorcontrib><creatorcontrib>ONG, Voon</creatorcontrib><creatorcontrib>YEH, Li-Tain</creatorcontrib><creatorcontrib>QUART, Barry</creatorcontrib><creatorcontrib>STOEHR, Albrecht</creatorcontrib><creatorcontrib>RIEGER, Armin</creatorcontrib><creatorcontrib>SHEN, Zancong</creatorcontrib><creatorcontrib>MANHARD, Kimberly</creatorcontrib><creatorcontrib>SHEEDY, Beth</creatorcontrib><creatorcontrib>HINGORANI, Vijay</creatorcontrib><creatorcontrib>RANEY, Anneke</creatorcontrib><creatorcontrib>NGUYEN, Mai</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial Agents and Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOYLE, Graeme</au><au>BOFFITO, Marta</au><au>NGUYEN, Tranh</au><au>ONG, Voon</au><au>YEH, Li-Tain</au><au>QUART, Barry</au><au>STOEHR, Albrecht</au><au>RIEGER, Armin</au><au>SHEN, Zancong</au><au>MANHARD, Kimberly</au><au>SHEEDY, Beth</au><au>HINGORANI, Vijay</au><au>RANEY, Anneke</au><au>NGUYEN, Mai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naïve Subjects</atitle><jtitle>Antimicrobial Agents and Chemotherapy</jtitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>54</volume><issue>8</issue><spage>3170</spage><epage>3178</epage><pages>3170-3178</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Classifications
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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>20498326</pmid><doi>10.1128/AAC.00268-10</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2010-08, Vol.54 (8), p.3170-3178 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pubmed_primary_20498326 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Dose-Response Relationship, Drug Double-Blind Method HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Pharmacology Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects Reverse Transcriptase Inhibitors - pharmacokinetics Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - blood Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Young Adult |
| title | Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naïve Subjects |
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