Etanercept and neoplasms

The introduction of tumor necrosis factor (TNF) beta blockers has make it possible to obtain a significant advance in the control and knowledge of some inflammatory diseases, among them psoriasis. TNF is a cytokine that plays a key role in the control of infections and neoplasms. The increase of the...

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Veröffentlicht in:Actas dermo-sifiliográficas (English ed.) 2010-05, Vol.101 Suppl 1, p.88
Hauptverfasser: García-Rabasco, A, Sánchez-Carazo, J L, Esteve, A
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container_title Actas dermo-sifiliográficas (English ed.)
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creator García-Rabasco, A
Sánchez-Carazo, J L
Esteve, A
description The introduction of tumor necrosis factor (TNF) beta blockers has make it possible to obtain a significant advance in the control and knowledge of some inflammatory diseases, among them psoriasis. TNF is a cytokine that plays a key role in the control of infections and neoplasms. The increase of the risk of developing a neoplasm during the use of this group of drugs is one of the more debated adverse effects in the literature. We present the clinical case of one patient with long-course psoriasis who developed a breast adenocarcinoma after initiating treatment with etanercept. In this article, we provide a brief review on the possible associations existing between the use of anti-TNF therapy and the risk of the appearance of come neoplasms, among which leukemias, lymphomas and some solid tumors stand out.
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subjects Adenocarcinoma - chemically induced
Adult
Breast Neoplasms - chemically induced
Decision Trees
Etanercept
Female
Humans
Immunoglobulin G - adverse effects
Psoriasis - drug therapy
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha - antagonists & inhibitors
title Etanercept and neoplasms
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