Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis

Cyclooxygenase-2 (COX-2) inhibition prevents adenoma formation in humans and mouse models of colon cancer. The selective COX-2 inhibitor celecoxib reduces COX-2 and prostaglandin E(2) (PGE(2)) expression and adenomas in the intestine of Min/+ mice after treatment for several weeks, but prolonged tre...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-06, Vol.70 (11), p.4433
Hauptverfasser:	Carothers, Adelaide M, Davids, Jennifer S, Damas, Beatrice C, Bertagnolli, Monica M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - biosynthesis Celecoxib Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Colitis - enzymology Colitis - metabolism Colitis - pathology Colonic Neoplasms - blood supply Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - prevention & control Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Down-Regulation Ileum - blood supply Ileum - enzymology Ileum - metabolism Ileum - pathology Interleukin-1beta - biosynthesis MAP Kinase Kinase Kinases - metabolism Mice Mice, Inbred C57BL NF-kappa B - metabolism Pyrazoles - pharmacology Sulfonamides - pharmacology Toll-Like Receptors - metabolism
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