Inhibitor of IkappaB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells

Plasmacytoid dendritic cells (pDCs) play not only a central role in the antiviral immune response in innate host defense, but also a pathogenic role in the development of the autoimmune process by their ability to produce robust amounts of type I interferons (IFNs), through sensing nucleic acids by...

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Veröffentlicht in:	Arthritis research & therapy 2010, Vol.12 (3), p.R87
Hauptverfasser:	Miyamoto, Rie, Ito, Tomoki, Nomura, Shosaku, Amakawa, Ryuichi, Amuro, Hideki, Katashiba, Yuichi, Ogata, Makoto, Murakami, Naoko, Shimamoto, Keiko, Yamazaki, Chihiro, Hoshino, Katsuaki, Kaisho, Tsuneyasu, Fukuhara, Shirou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological Transport - drug effects Cell Nucleus - metabolism Cells, Cultured Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Dose-Response Relationship, Drug Humans I-kappa B Kinase - antagonists & inhibitors I-kappa B Kinase - metabolism Interferon Regulatory Factor-7 - metabolism Interferon Type I - metabolism Interferon-alpha - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lupus Erythematosus, Systemic - metabolism Lupus Erythematosus, Systemic - pathology Mice Mice, Inbred C57BL Models, Animal Nitriles - pharmacology Sulfones - pharmacology
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