KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation

Localized chromatin modifications of histone tails play an important role in regulating gene transcription, and aberration of these processes leads to carcinogenesis. Methylated histone lysine residues, a key player in chromatin remodeling, are demethylated by the JmjC class of enzymes. Here we show...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-05, Vol.107 (21), p.9671-9676
Hauptverfasser:	Hsia, Datsun A., Tepper, Clifford G., Pochampalli, Mamata R., Hsia, Elaine Y. C., Izumiya, Chie, Huerta, Steve B., Wright, Michael E., Chen, Hong-Wu, Kung, Hsing-Jien, Izumiya, Yoshihiro, Wang, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antibodies Biological Sciences Breast cancer Cancer Cell cycle Cell growth Cell Line, Tumor Cell lines Cell Proliferation Cellular biology Cyclin A1 - genetics Cyclin A1 - metabolism Cyclins Enzymes Gene expression Gene Expression Regulation, Neoplastic Germ cells Histone Demethylases - genetics Histone Demethylases - metabolism Histones Histones - metabolism Humans Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Open Reading Frames Promoter regions Ribonucleic acid RNA RNA Interference Transcription, Genetic Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!