8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and form...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2010-05, Vol.107 (21), p.9742-9746 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 107 |
| creator | Ahmadiyeh, Nasim Pomerantz, Mark M Grisanzio, Chiara Herman, Paula Jia, Li Almendro, Vanessa He, Housheng Hansen Brown, Myles Liu, X. Shirley Davis, Matt Caswell, Jennifer L Beckwith, Christine A Hills, Adam MacConaill, Laura Coetzee, Gerhard A Regan, Meredith M Freedman, Matthew L |
| description | The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism--as tissue-specific enhancers of MYC. |
| doi_str_mv | 10.1073/pnas.0910668107 |
| format | Article |
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Shirley ; Davis, Matt ; Caswell, Jennifer L ; Beckwith, Christine A ; Hills, Adam ; MacConaill, Laura ; Coetzee, Gerhard A ; Regan, Meredith M ; Freedman, Matthew L</creator><creatorcontrib>Ahmadiyeh, Nasim ; Pomerantz, Mark M ; Grisanzio, Chiara ; Herman, Paula ; Jia, Li ; Almendro, Vanessa ; He, Housheng Hansen ; Brown, Myles ; Liu, X. Shirley ; Davis, Matt ; Caswell, Jennifer L ; Beckwith, Christine A ; Hills, Adam ; MacConaill, Laura ; Coetzee, Gerhard A ; Regan, Meredith M ; Freedman, Matthew L</creatorcontrib><description>The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism--as tissue-specific enhancers of MYC.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0910668107</identifier><identifier>PMID: 20453196</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Biological Sciences ; Breast cancer ; Breast Neoplasms - genetics ; Cancer ; Cell Line, Tumor ; Cell lines ; Chromatin ; Chromosomes ; Chromosomes, Human, Pair 8 ; Colonic Neoplasms - genetics ; Colorectal cancer ; Epigenesis, Genetic ; Epigenetics ; Gene Expression Regulation, Neoplastic ; Genes ; Genetic Loci ; Genome, Human ; Humans ; Ligation ; Organ Specificity ; Prostate ; Prostate cancer ; Proto-Oncogene Proteins c-myc - genetics ; Risk Factors ; Studies ; Tissues</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (21), p.9742-9746</ispartof><rights>Copyright National Academy of Sciences May 25, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-45a017d79d7d96eb82e719e2857304ea0c1a684dcb8da07a4b312b1e05fee74c3</citedby><cites>FETCH-LOGICAL-c489t-45a017d79d7d96eb82e719e2857304ea0c1a684dcb8da07a4b312b1e05fee74c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/107/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25681670$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25681670$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20453196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmadiyeh, Nasim</creatorcontrib><creatorcontrib>Pomerantz, Mark M</creatorcontrib><creatorcontrib>Grisanzio, Chiara</creatorcontrib><creatorcontrib>Herman, Paula</creatorcontrib><creatorcontrib>Jia, Li</creatorcontrib><creatorcontrib>Almendro, Vanessa</creatorcontrib><creatorcontrib>He, Housheng Hansen</creatorcontrib><creatorcontrib>Brown, Myles</creatorcontrib><creatorcontrib>Liu, X. Shirley</creatorcontrib><creatorcontrib>Davis, Matt</creatorcontrib><creatorcontrib>Caswell, Jennifer L</creatorcontrib><creatorcontrib>Beckwith, Christine A</creatorcontrib><creatorcontrib>Hills, Adam</creatorcontrib><creatorcontrib>MacConaill, Laura</creatorcontrib><creatorcontrib>Coetzee, Gerhard A</creatorcontrib><creatorcontrib>Regan, Meredith M</creatorcontrib><creatorcontrib>Freedman, Matthew L</creatorcontrib><title>8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. 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We therefore propose that the 8q24 risk loci operate through a common mechanism--as tissue-specific enhancers of MYC.</description><subject>Biological Sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cell lines</subject><subject>Chromatin</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 8</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colorectal cancer</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Genetic Loci</subject><subject>Genome, Human</subject><subject>Humans</subject><subject>Ligation</subject><subject>Organ Specificity</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Tissues</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9vFCEUxydGY7fVsyeV9OKl0z4YZoBLE7PxV1LjQXvwRBjmzS7rLGyBtfG_l82uXfVE4H3e5wHfqnpB4ZKCaK423qRLUBS6TpaDR9WMll3dcQWPqxkAE7XkjJ9UpymtAEC1Ep5WJwx421DVzapR3jFONjGkbDJekD6iSfmCGD8QG6bgiTXeYiTRpR9kCtaRtAz3JLuUtlinDVo3OlsqflFH4xdInM8Yjc2uNN-7vCSfv8-fVU9GMyV8fljPqtv3777NP9Y3Xz58mr-9qS2XKte8NUDFINQgBtVhLxkKqpDJVjTA0YClppN8sL0cDAjD-4ayniK0I6LgtjmrrvfezbZf42DR52gmvYlubeIvHYzT_1a8W-pF-KmZgiLmRfDmIIjhbosp67VLFqfJeAzbpEXTUOBKdYU8_49chW305XW64YJzylpWoKs9ZMsPp4jjw1Uo6F2CepegPiZYOl79_YIH_k9kBXh9AHadR53QjGol-G7oyz2xSjnEo6EtEzoBR8NogjaLkqy-_cqANkAlF0LK5jfZXbT1</recordid><startdate>20100525</startdate><enddate>20100525</enddate><creator>Ahmadiyeh, Nasim</creator><creator>Pomerantz, Mark M</creator><creator>Grisanzio, Chiara</creator><creator>Herman, Paula</creator><creator>Jia, Li</creator><creator>Almendro, Vanessa</creator><creator>He, Housheng Hansen</creator><creator>Brown, Myles</creator><creator>Liu, X. 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In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism--as tissue-specific enhancers of MYC.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>20453196</pmid><doi>10.1073/pnas.0910668107</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological Sciences Breast cancer Breast Neoplasms - genetics Cancer Cell Line, Tumor Cell lines Chromatin Chromosomes Chromosomes, Human, Pair 8 Colonic Neoplasms - genetics Colorectal cancer Epigenesis, Genetic Epigenetics Gene Expression Regulation, Neoplastic Genes Genetic Loci Genome, Human Humans Ligation Organ Specificity Prostate Prostate cancer Proto-Oncogene Proteins c-myc - genetics Risk Factors Studies Tissues |
| title | 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC |
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