Cryptococcus meningitis in an immunocompetent child: a case report
Cryptococcus meningitis is uncommon in childhood. We report a Senegalese case of cryptococcus meningitis diagnosed in an apparently immunocompetent child. A 9-year-old boy was admitted for acute meningoencephalitis. A computerized tomography scan of the brain showed an ischemic lesion in the left ca...
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| Veröffentlicht in: | Archives de pédiatrie : organe officiel de la Société française de pédiatrie 2010-07, Vol.17 (7), p.1069 |
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| container_title | Archives de pédiatrie : organe officiel de la Société française de pédiatrie |
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| creator | Ndiaye, M Hagerimana, R Diagne, N S Faye, M W Sène, M S Sow, A D Sène-Diouf, F Diop, A G Ndiaye, M M |
| description | Cryptococcus meningitis is uncommon in childhood. We report a Senegalese case of cryptococcus meningitis diagnosed in an apparently immunocompetent child. A 9-year-old boy was admitted for acute meningoencephalitis. A computerized tomography scan of the brain showed an ischemic lesion in the left caudate and study of cerebrospinal fluid (CSF) revealed cytological and biochemical abnormalities and Cryptococcus neoformans on direct exam and culture. HIV and syphilis antibodies were negative and the blood CD4 lymphocyte count was 804/mm(3). The child had no immunocompromising factors such as hematologic abnormalities, solid tumor, or undernutrition. He was treated with fluconazole intravenously, but clinical outcome was unsuccessful. The patient died after 1 month from cardiovascular and respiratory distress. |
| doi_str_mv | 10.1016/j.arcped.2010.03.003 |
| format | Article |
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We report a Senegalese case of cryptococcus meningitis diagnosed in an apparently immunocompetent child. A 9-year-old boy was admitted for acute meningoencephalitis. A computerized tomography scan of the brain showed an ischemic lesion in the left caudate and study of cerebrospinal fluid (CSF) revealed cytological and biochemical abnormalities and Cryptococcus neoformans on direct exam and culture. HIV and syphilis antibodies were negative and the blood CD4 lymphocyte count was 804/mm(3). The child had no immunocompromising factors such as hematologic abnormalities, solid tumor, or undernutrition. He was treated with fluconazole intravenously, but clinical outcome was unsuccessful. The patient died after 1 month from cardiovascular and respiratory distress.</description><identifier>EISSN: 1769-664X</identifier><identifier>DOI: 10.1016/j.arcped.2010.03.003</identifier><identifier>PMID: 20400277</identifier><language>fre</language><publisher>France</publisher><subject>Antifungal Agents - therapeutic use ; Child ; Cryptococcosis - diagnosis ; Cryptococcosis - drug therapy ; Cryptococcus neoformans - isolation & purification ; Fatal Outcome ; Fluconazole - therapeutic use ; Humans ; Immunocompetence ; Male ; Meningitis, Fungal - diagnosis ; Meningitis, Fungal - drug therapy</subject><ispartof>Archives de pédiatrie : organe officiel de la Société française de pédiatrie, 2010-07, Vol.17 (7), p.1069</ispartof><rights>Copyright (c) 2010 Elsevier Masson SAS. 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We report a Senegalese case of cryptococcus meningitis diagnosed in an apparently immunocompetent child. A 9-year-old boy was admitted for acute meningoencephalitis. A computerized tomography scan of the brain showed an ischemic lesion in the left caudate and study of cerebrospinal fluid (CSF) revealed cytological and biochemical abnormalities and Cryptococcus neoformans on direct exam and culture. HIV and syphilis antibodies were negative and the blood CD4 lymphocyte count was 804/mm(3). The child had no immunocompromising factors such as hematologic abnormalities, solid tumor, or undernutrition. He was treated with fluconazole intravenously, but clinical outcome was unsuccessful. The patient died after 1 month from cardiovascular and respiratory distress.</description><subject>Antifungal Agents - therapeutic use</subject><subject>Child</subject><subject>Cryptococcosis - diagnosis</subject><subject>Cryptococcosis - drug therapy</subject><subject>Cryptococcus neoformans - isolation & purification</subject><subject>Fatal Outcome</subject><subject>Fluconazole - therapeutic use</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>Male</subject><subject>Meningitis, Fungal - diagnosis</subject><subject>Meningitis, Fungal - drug therapy</subject><issn>1769-664X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8FKxDAURYMgzjj6ByL5gdaXpH1N3WlxVBhwo-BuSNNUM0zSkKSL-XsL6urCOXDgEnLDoGTA8O5QqqiDGUoOCwJRAogzsmYNtgVi9bkilykdAECCFBdkxaEC4E2zJo9dPIU86UnrOVFnvPVfNttErafKU-vc7BfrgsnGZ6q_7XG4p4pqlQyNJkwxX5HzUR2Tuf7bDfnYPr13L8Xu7fm1e9gVgYHMhWJSN9hjrYUUKBTXwiCvpIaR49jW7aIBsTFy4Avi3PS1HhgIbCVDLcWG3P52w9w7M-xDtE7F0_7_jPgBMJlLZA</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Ndiaye, M</creator><creator>Hagerimana, R</creator><creator>Diagne, N S</creator><creator>Faye, M W</creator><creator>Sène, M S</creator><creator>Sow, A D</creator><creator>Sène-Diouf, F</creator><creator>Diop, A G</creator><creator>Ndiaye, M M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201007</creationdate><title>Cryptococcus meningitis in an immunocompetent child: a case report</title><author>Ndiaye, M ; Hagerimana, R ; Diagne, N S ; Faye, M W ; Sène, M S ; Sow, A D ; Sène-Diouf, F ; Diop, A G ; Ndiaye, M M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p108t-a18c76b65c38363a2c3e6248c0f26f9598c70667e8d20f222eb5cd10369816c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2010</creationdate><topic>Antifungal Agents - therapeutic use</topic><topic>Child</topic><topic>Cryptococcosis - diagnosis</topic><topic>Cryptococcosis - drug therapy</topic><topic>Cryptococcus neoformans - isolation & purification</topic><topic>Fatal Outcome</topic><topic>Fluconazole - therapeutic use</topic><topic>Humans</topic><topic>Immunocompetence</topic><topic>Male</topic><topic>Meningitis, Fungal - diagnosis</topic><topic>Meningitis, Fungal - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ndiaye, M</creatorcontrib><creatorcontrib>Hagerimana, R</creatorcontrib><creatorcontrib>Diagne, N S</creatorcontrib><creatorcontrib>Faye, M W</creatorcontrib><creatorcontrib>Sène, M S</creatorcontrib><creatorcontrib>Sow, A D</creatorcontrib><creatorcontrib>Sène-Diouf, F</creatorcontrib><creatorcontrib>Diop, A G</creatorcontrib><creatorcontrib>Ndiaye, M M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Archives de pédiatrie : organe officiel de la Société française de pédiatrie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ndiaye, M</au><au>Hagerimana, R</au><au>Diagne, N S</au><au>Faye, M W</au><au>Sène, M S</au><au>Sow, A D</au><au>Sène-Diouf, F</au><au>Diop, A G</au><au>Ndiaye, M M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cryptococcus meningitis in an immunocompetent child: a case report</atitle><jtitle>Archives de pédiatrie : organe officiel de la Société française de pédiatrie</jtitle><addtitle>Arch Pediatr</addtitle><date>2010-07</date><risdate>2010</risdate><volume>17</volume><issue>7</issue><spage>1069</spage><pages>1069-</pages><eissn>1769-664X</eissn><abstract>Cryptococcus meningitis is uncommon in childhood. 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| fulltext | fulltext |
| identifier | EISSN: 1769-664X |
| ispartof | Archives de pédiatrie : organe officiel de la Société française de pédiatrie, 2010-07, Vol.17 (7), p.1069 |
| issn | 1769-664X |
| language | fre |
| recordid | cdi_pubmed_primary_20400277 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antifungal Agents - therapeutic use Child Cryptococcosis - diagnosis Cryptococcosis - drug therapy Cryptococcus neoformans - isolation & purification Fatal Outcome Fluconazole - therapeutic use Humans Immunocompetence Male Meningitis, Fungal - diagnosis Meningitis, Fungal - drug therapy |
| title | Cryptococcus meningitis in an immunocompetent child: a case report |
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