Acute myeloid leukemia with t(9;11)(p21-22;q23): common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases

We compared pathogenetic features of 32 de novo and 29 therapy-related (t) t(9;11)(p21-22;q23)/MLLT3-MLL acute myeloid leukemia (AML) cases to identify progression factors and to assess whether distinction between these manifestations is warranted. MLLT3-MLL rearrangement was commonly the sole karyo...

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Veröffentlicht in:	American journal of clinical pathology 2010-05, Vol.133 (5), p.686
Hauptverfasser:	Chandra, Pranil, Luthra, Rajyalakshmi, Zuo, Zhuang, Yao, Hui, Ravandi, Farhad, Reddy, Neeli, Garcia-Manero, Guillermo, Kantarjian, Hagop, Jones, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 9 Disease Progression Female Gene Expression Profiling Gene Rearrangement Histone-Lysine N-Methyltransferase Humans Infant Leukemia, Myelomonocytic, Acute - genetics Leukemia, Myelomonocytic, Acute - mortality Leukemia, Myelomonocytic, Acute - pathology Male MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Myeloid-Lymphoid Leukemia Protein - genetics Nuclear Proteins - genetics Point Mutation ras Proteins - genetics ras Proteins - metabolism Signal Transduction Survival Rate Texas - epidemiology Translocation, Genetic Young Adult
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