Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P450(17alpha) and P450(scc)

Polychlorinated biphenyls (PCBs) are environmental pollutants that are quite toxic to biological systems. This study examined the inhibitory effect of PCB126 and PCB114 on testicular steroidogenesis in male rats. Male Sprague Dawley rats received weekly intraperitoneal injections of PCB126 (0.2 mg/k...

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Veröffentlicht in:	Toxicology and industrial health 2010-06, Vol.26 (5), p.287
Hauptverfasser:	Han, Dae-Yong, Kang, Sang-Rim, Park, Oh-Sung, Cho, Jae-Hyeon, Won, Chung-Kil, Park, Hyeon-Soo, Park, Kwang-Il, Kim, Eun-Hee, Kim, Gon-Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cholesterol Side-Chain Cleavage Enzyme - biosynthesis Cholesterol Side-Chain Cleavage Enzyme - genetics Cholesterol Side-Chain Cleavage Enzyme - metabolism Down-Regulation - drug effects Follicle Stimulating Hormone - biosynthesis Follicle Stimulating Hormone - blood Gene Expression Profiling Humans Luteinizing Hormone - biosynthesis Luteinizing Hormone - blood Male Organ Size - drug effects Polychlorinated Biphenyls - pharmacology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Steroid 17-alpha-Hydroxylase - biosynthesis Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism Steroids - antagonists & inhibitors Steroids - biosynthesis Testis - anatomy & histology Testis - drug effects Testis - metabolism Testosterone - biosynthesis Testosterone - blood
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