Phylogenetic Approach to the Variability of the Microsporidian Enterocytozoon bieneusi and Its Implications for Inter- and Intrahost Transmission
Enterocytozoon bieneusi is a microsporidian parasite that infects many vertebrate animals, including humans. The rDNA internal transcribed spacer (ITS) shows a hypervariable sequence; however, so far no clear information has been inferred about strain evolution in this species. We reviewed all the s...
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| Veröffentlicht in: | Applied and Environmental Microbiology 2010-05, Vol.76 (10), p.3333-3342 |
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| creator | Henriques-Gil, Nuno Haro, María Izquierdo, Fernando Fenoy, Soledad del Águila, Carmen |
| description | Enterocytozoon bieneusi is a microsporidian parasite that infects many vertebrate animals, including humans. The rDNA internal transcribed spacer (ITS) shows a hypervariable sequence; however, so far no clear information has been inferred about strain evolution in this species. We reviewed all the sequences described and performed a phylogenetic study. Four groups of sequences strongly differentiated from each other were detected, although most of the isolates (94%) corresponded to group I. The highly diverse sequences of this group were analyzed using median-joining networks. The host species (humans, pets, swine, cattle, birds, and wild animals) and the continents of origin of the isolates were considered. Central haplotypes in the network were obtained from very diverse hosts and geographical origins. The results show that although E. bieneusi has a broad host specificity, transmission is not completely free: some strains were able to circulate within a given host species and were only occasionally transmitted to another host. Additionally, while not relevant for swine or cattle hosts, geography seems to be a relevant factor for human infection by E. bieneusi. |
| doi_str_mv | 10.1128/AEM.03026-09 |
| format | Article |
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The rDNA internal transcribed spacer (ITS) shows a hypervariable sequence; however, so far no clear information has been inferred about strain evolution in this species. We reviewed all the sequences described and performed a phylogenetic study. Four groups of sequences strongly differentiated from each other were detected, although most of the isolates (94%) corresponded to group I. The highly diverse sequences of this group were analyzed using median-joining networks. The host species (humans, pets, swine, cattle, birds, and wild animals) and the continents of origin of the isolates were considered. Central haplotypes in the network were obtained from very diverse hosts and geographical origins. The results show that although E. bieneusi has a broad host specificity, transmission is not completely free: some strains were able to circulate within a given host species and were only occasionally transmitted to another host. Additionally, while not relevant for swine or cattle hosts, geography seems to be a relevant factor for human infection by E. bieneusi.</description><identifier>ISSN: 0099-2240</identifier><identifier>EISSN: 1098-5336</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AEM.03026-09</identifier><identifier>PMID: 20228101</identifier><identifier>CODEN: AEMIDF</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Animal diseases ; Animals ; Animals, Wild - microbiology ; Bacteria ; Biological and medical sciences ; Cattle ; Cattle Diseases - microbiology ; Disease transmission ; DNA, Ribosomal Spacer - genetics ; Enterocytozoon - classification ; Enterocytozoon - genetics ; Enterocytozoon - isolation & purification ; Enterocytozoon bieneusi ; Evolutionary and Genomic Microbiology ; Fundamental and applied biological sciences. 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The rDNA internal transcribed spacer (ITS) shows a hypervariable sequence; however, so far no clear information has been inferred about strain evolution in this species. We reviewed all the sequences described and performed a phylogenetic study. Four groups of sequences strongly differentiated from each other were detected, although most of the isolates (94%) corresponded to group I. The highly diverse sequences of this group were analyzed using median-joining networks. The host species (humans, pets, swine, cattle, birds, and wild animals) and the continents of origin of the isolates were considered. Central haplotypes in the network were obtained from very diverse hosts and geographical origins. The results show that although E. bieneusi has a broad host specificity, transmission is not completely free: some strains were able to circulate within a given host species and were only occasionally transmitted to another host. Additionally, while not relevant for swine or cattle hosts, geography seems to be a relevant factor for human infection by E. bieneusi.</description><subject>Animal diseases</subject><subject>Animals</subject><subject>Animals, Wild - microbiology</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cattle Diseases - microbiology</subject><subject>Disease transmission</subject><subject>DNA, Ribosomal Spacer - genetics</subject><subject>Enterocytozoon - classification</subject><subject>Enterocytozoon - genetics</subject><subject>Enterocytozoon - isolation & purification</subject><subject>Enterocytozoon bieneusi</subject><subject>Evolutionary and Genomic Microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Humans</subject><subject>Microbiology</subject><subject>Microsporidiosis - microbiology</subject><subject>Microsporidiosis - transmission</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Ribosomal DNA</subject><subject>Swine</subject><subject>Swine Diseases - microbiology</subject><issn>0099-2240</issn><issn>1098-5336</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-P1CAYxonRuOPozbMSE-PFrvwrhYvJZDPqJLvRxF2vhFI6ZdOWCoxm_BZ-Y-nOuKte5ELC--N5nxceAJ5idIoxEW9W64tTRBHhBZL3wAIjKYqSUn4fLBCSsiCEoRPwKMZrhBBDXDwEJwQRIjDCC_DzU7fv_daONjkDV9MUvDYdTB6mzsIvOjhdu96lPfTtzdGFM8HHyQfXOD3C9Zhs8Gaf_A_vR1i7rLSLDuqxgZsU4WaYemd0cn6MsPUBbuYLxaE-pqA7HxO8DHqMg4sxY4_Bg1b30T457ktw9W59efahOP_4fnO2Oi9MSWgqcMNqwikhDTEVtYJpZgnTyJrKIMJawyohOGeI6rrFhlnOSqy55URWthGGLsHbg-60qwfbGDu76dUU3KDDXnnt1N-V0XVq678pIrjEuMoCr44CwX_d2ZhUnsDYvtej9buoKlZKMhv4P0lpKSvJeCZf_ENe-10Y8zsogkrJOc7DL8HrAzT_RAy2vTWNkZozoXIm1E0mFJIZf_bnoLfw7xBk4OUR0NHovs2fYVy840hVMSLYnbnObbvvLlil46C0HVTF59Z0Xkvw_AC12iu9DVno6jPJXRAWVJTZ_i_O7dXB</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Henriques-Gil, Nuno</creator><creator>Haro, María</creator><creator>Izquierdo, Fernando</creator><creator>Fenoy, Soledad</creator><creator>del Águila, Carmen</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100501</creationdate><title>Phylogenetic Approach to the Variability of the Microsporidian Enterocytozoon bieneusi and Its Implications for Inter- and Intrahost Transmission</title><author>Henriques-Gil, Nuno ; Haro, María ; Izquierdo, Fernando ; Fenoy, Soledad ; del Águila, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-1d4b26322d2c73e84a4e24a0ec7c024fc478866403abf1c4e6451a6e6297ed8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animal diseases</topic><topic>Animals</topic><topic>Animals, Wild - microbiology</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cattle Diseases - microbiology</topic><topic>Disease transmission</topic><topic>DNA, Ribosomal Spacer - genetics</topic><topic>Enterocytozoon - classification</topic><topic>Enterocytozoon - genetics</topic><topic>Enterocytozoon - isolation & purification</topic><topic>Enterocytozoon bieneusi</topic><topic>Evolutionary and Genomic Microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Humans</topic><topic>Microbiology</topic><topic>Microsporidiosis - microbiology</topic><topic>Microsporidiosis - transmission</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Ribosomal DNA</topic><topic>Swine</topic><topic>Swine Diseases - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henriques-Gil, Nuno</creatorcontrib><creatorcontrib>Haro, María</creatorcontrib><creatorcontrib>Izquierdo, Fernando</creatorcontrib><creatorcontrib>Fenoy, Soledad</creatorcontrib><creatorcontrib>del Águila, Carmen</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Applied and Environmental Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henriques-Gil, Nuno</au><au>Haro, María</au><au>Izquierdo, Fernando</au><au>Fenoy, Soledad</au><au>del Águila, Carmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phylogenetic Approach to the Variability of the Microsporidian Enterocytozoon bieneusi and Its Implications for Inter- and Intrahost Transmission</atitle><jtitle>Applied and Environmental Microbiology</jtitle><addtitle>Appl Environ Microbiol</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>76</volume><issue>10</issue><spage>3333</spage><epage>3342</epage><pages>3333-3342</pages><issn>0099-2240</issn><eissn>1098-5336</eissn><eissn>1098-6596</eissn><coden>AEMIDF</coden><abstract>Enterocytozoon bieneusi is a microsporidian parasite that infects many vertebrate animals, including humans. The rDNA internal transcribed spacer (ITS) shows a hypervariable sequence; however, so far no clear information has been inferred about strain evolution in this species. We reviewed all the sequences described and performed a phylogenetic study. Four groups of sequences strongly differentiated from each other were detected, although most of the isolates (94%) corresponded to group I. The highly diverse sequences of this group were analyzed using median-joining networks. The host species (humans, pets, swine, cattle, birds, and wild animals) and the continents of origin of the isolates were considered. Central haplotypes in the network were obtained from very diverse hosts and geographical origins. The results show that although E. bieneusi has a broad host specificity, transmission is not completely free: some strains were able to circulate within a given host species and were only occasionally transmitted to another host. Additionally, while not relevant for swine or cattle hosts, geography seems to be a relevant factor for human infection by E. bieneusi.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>20228101</pmid><doi>10.1128/AEM.03026-09</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | American Society for Microbiology; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animal diseases Animals Animals, Wild - microbiology Bacteria Biological and medical sciences Cattle Cattle Diseases - microbiology Disease transmission DNA, Ribosomal Spacer - genetics Enterocytozoon - classification Enterocytozoon - genetics Enterocytozoon - isolation & purification Enterocytozoon bieneusi Evolutionary and Genomic Microbiology Fundamental and applied biological sciences. Psychology Genetic Variation Genotype Humans Microbiology Microsporidiosis - microbiology Microsporidiosis - transmission Phylogenetics Phylogeny Ribosomal DNA Swine Swine Diseases - microbiology |
| title | Phylogenetic Approach to the Variability of the Microsporidian Enterocytozoon bieneusi and Its Implications for Inter- and Intrahost Transmission |
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