Possible Involvement of Transthyretin in Hippocampal β-Amyloid Burden and Learning Behaviors in a Mouse Model of Alzheimer’s Disease (TgCRND8)

Background: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss, possibly triggered by the accumulation of β-amyloid (Aβ) peptides and the hyperphosphorylation of Tau neurofilament protein. Recent findings have shown that transthyretin (TTR) is a potent s...

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Veröffentlicht in:	Neuro-degenerative diseases 2010-01, Vol.7 (1-3), p.88-95
Hauptverfasser:	Doggui, Sihem, Brouillette, Jonathan, Chabot, Jean-Guy, Farso, Mark, Quirion, Rémi
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alzheimer Disease - complications Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Animals Disease Models Disease Models, Animal Hippocampus - metabolism Learning Disorders - etiology Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Transgenic Prealbumin - deficiency Prealbumin - metabolism
Online-Zugang:	Volltext
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