Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy

Human mesenchymal stem cells (hMSCs) from bone marrow are regarded as putative osteoblast progenitors in vivo and differentiate into osteoblasts in vitro. Positive signaling by the canonical wingless (Wnt) pathway is critical for the differentiation of MSCs into osteoblasts. In contrast, activation...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-03, Vol.107 (9), p.4147-4152
Hauptverfasser:	Krause, Ulf, Harris, Sean, Green, Angela, Ylostalo, Joni, Zeitouni, Suzanne, Lee, Narae, Gregory, Carl A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism beta Catenin - metabolism Biocompatible Materials Biological Sciences Blood vessels Bone formation Bone marrow Bones Cell cycle Cultured cells Enzyme Inhibitors - pharmacology Gene Expression Profiling Genes Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Indoles - pharmacology Intercellular Signaling Peptides and Proteins - metabolism Lesions Lipogenesis Mesenchymal stem cells Multipotent Stem Cells - drug effects Multipotent Stem Cells - enzymology Multipotent Stem Cells - metabolism Osteoblasts Osteogenesis - drug effects Osteoprotegerin - metabolism Oximes - pharmacology Pharmaceuticals PPAR gamma - antagonists & inhibitors Signal transduction Signal Transduction - drug effects Stem cells Stromal Cells - drug effects Stromal Cells - enzymology Stromal Cells - metabolism Tissue Engineering Wnt Proteins - metabolism
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