Systemic histopathology of rats with CCl4-induced hepatic cirrhosis
Systemic histopathological examinations were carried out on rats with CCl4-induced hepatic cirrhosis. Moderate congestion in the spleen, prominent oedema and focal acinar cell degeneration in the pancreas, marked haemorrhage and phagocytosis of haemosiderin by macrophages in the pancreaticoduodenal...
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| Veröffentlicht in: | Laboratory animals (London) 1991-01, Vol.25 (1), p.21-25 |
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| creator | Doi, K Kurabe, S Shimazu, N Inagaki, M |
| description | Systemic histopathological examinations were carried out on rats with CCl4-induced hepatic cirrhosis. Moderate congestion in the spleen, prominent oedema and focal acinar cell degeneration in the pancreas, marked haemorrhage and phagocytosis of haemosiderin by macrophages in the pancreaticoduodenal lymph node, appearance of monocytes bearing haemosiderinlike granules in the pulmonary arteries and cardiac right atrium, and focal segmental glomerulosclerosis were consistently observed in rats with hepatic cirrhosis. In addition, a marked increase in number of target cells and the appearance of a small number of monocytes bearing haemosiderinlike granules were also commonly found in the peripheral blood smears of these animals. These findings are considered to be important in the use of the CCl4-induced model of hepatic cirrhosis in the rat. |
| doi_str_mv | 10.1258/002367791780808121 |
| format | Article |
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Moderate congestion in the spleen, prominent oedema and focal acinar cell degeneration in the pancreas, marked haemorrhage and phagocytosis of haemosiderin by macrophages in the pancreaticoduodenal lymph node, appearance of monocytes bearing haemosiderinlike granules in the pulmonary arteries and cardiac right atrium, and focal segmental glomerulosclerosis were consistently observed in rats with hepatic cirrhosis. In addition, a marked increase in number of target cells and the appearance of a small number of monocytes bearing haemosiderinlike granules were also commonly found in the peripheral blood smears of these animals. These findings are considered to be important in the use of the CCl4-induced model of hepatic cirrhosis in the rat.</description><identifier>ISSN: 0023-6772</identifier><identifier>EISSN: 1758-1117</identifier><identifier>DOI: 10.1258/002367791780808121</identifier><identifier>PMID: 2010972</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Carbon Tetrachloride ; Heart Atria - drug effects ; Liver Cirrhosis - chemically induced ; Liver Cirrhosis - pathology ; Macrophages - ultrastructure ; Male ; Monocytes - ultrastructure ; Organ Specificity ; Phagocytosis ; Pulmonary Artery - drug effects ; Rats ; Rats, Inbred Strains</subject><ispartof>Laboratory animals (London), 1991-01, Vol.25 (1), p.21-25</ispartof><rights>1991 Royal Society of Medicine Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2010972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doi, K</creatorcontrib><creatorcontrib>Kurabe, S</creatorcontrib><creatorcontrib>Shimazu, N</creatorcontrib><creatorcontrib>Inagaki, M</creatorcontrib><title>Systemic histopathology of rats with CCl4-induced hepatic cirrhosis</title><title>Laboratory animals (London)</title><addtitle>Lab Anim</addtitle><description>Systemic histopathological examinations were carried out on rats with CCl4-induced hepatic cirrhosis. Moderate congestion in the spleen, prominent oedema and focal acinar cell degeneration in the pancreas, marked haemorrhage and phagocytosis of haemosiderin by macrophages in the pancreaticoduodenal lymph node, appearance of monocytes bearing haemosiderinlike granules in the pulmonary arteries and cardiac right atrium, and focal segmental glomerulosclerosis were consistently observed in rats with hepatic cirrhosis. In addition, a marked increase in number of target cells and the appearance of a small number of monocytes bearing haemosiderinlike granules were also commonly found in the peripheral blood smears of these animals. These findings are considered to be important in the use of the CCl4-induced model of hepatic cirrhosis in the rat.</description><subject>Animals</subject><subject>Carbon Tetrachloride</subject><subject>Heart Atria - drug effects</subject><subject>Liver Cirrhosis - chemically induced</subject><subject>Liver Cirrhosis - pathology</subject><subject>Macrophages - ultrastructure</subject><subject>Male</subject><subject>Monocytes - ultrastructure</subject><subject>Organ Specificity</subject><subject>Phagocytosis</subject><subject>Pulmonary Artery - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0023-6772</issn><issn>1758-1117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkN1KxDAQhYMoa119AUHoC8TN5KdpLqXoKix4oV6XpE22WdptaVqkb2-W3TuZi2E43wxzDkKPQJ6BinxDCGWZlApkTmIBhSuUgBQ5BgB5jZITgCNBb9FdCIc4As_JCq0oAaIkTVDxtYTJdr5KGx-mftBT07f9fkl7l456Cumvn5q0KFqO_bGeK1unjY1UXKj8ODZ98OEe3TjdBvtw6Wv08_b6Xbzj3ef2o3jZ4YHybMJGZYZzx4UBpZzKuATKBDDIjXESnM6YqlklmBImF4K5aIhZlYETilkCbI2ezneH2XS2LofRd3pcyouZqG_OetB7Wx76eTzGd0og5Smt8n9a7A8b3Fha</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>Doi, K</creator><creator>Kurabe, S</creator><creator>Shimazu, N</creator><creator>Inagaki, M</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19910101</creationdate><title>Systemic histopathology of rats with CCl4-induced hepatic cirrhosis</title><author>Doi, K ; Kurabe, S ; Shimazu, N ; Inagaki, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p246t-b96b44f45b199f964712351318bbf71fa639d3c5395b8553f8123e961f593e013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Carbon Tetrachloride</topic><topic>Heart Atria - drug effects</topic><topic>Liver Cirrhosis - chemically induced</topic><topic>Liver Cirrhosis - pathology</topic><topic>Macrophages - ultrastructure</topic><topic>Male</topic><topic>Monocytes - ultrastructure</topic><topic>Organ Specificity</topic><topic>Phagocytosis</topic><topic>Pulmonary Artery - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doi, K</creatorcontrib><creatorcontrib>Kurabe, S</creatorcontrib><creatorcontrib>Shimazu, N</creatorcontrib><creatorcontrib>Inagaki, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Laboratory animals (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doi, K</au><au>Kurabe, S</au><au>Shimazu, N</au><au>Inagaki, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic histopathology of rats with CCl4-induced hepatic cirrhosis</atitle><jtitle>Laboratory animals (London)</jtitle><addtitle>Lab Anim</addtitle><date>1991-01-01</date><risdate>1991</risdate><volume>25</volume><issue>1</issue><spage>21</spage><epage>25</epage><pages>21-25</pages><issn>0023-6772</issn><eissn>1758-1117</eissn><abstract>Systemic histopathological examinations were carried out on rats with CCl4-induced hepatic cirrhosis. Moderate congestion in the spleen, prominent oedema and focal acinar cell degeneration in the pancreas, marked haemorrhage and phagocytosis of haemosiderin by macrophages in the pancreaticoduodenal lymph node, appearance of monocytes bearing haemosiderinlike granules in the pulmonary arteries and cardiac right atrium, and focal segmental glomerulosclerosis were consistently observed in rats with hepatic cirrhosis. In addition, a marked increase in number of target cells and the appearance of a small number of monocytes bearing haemosiderinlike granules were also commonly found in the peripheral blood smears of these animals. These findings are considered to be important in the use of the CCl4-induced model of hepatic cirrhosis in the rat.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>2010972</pmid><doi>10.1258/002367791780808121</doi><tpages>5</tpages></addata></record> |
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| ispartof | Laboratory animals (London), 1991-01, Vol.25 (1), p.21-25 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Carbon Tetrachloride Heart Atria - drug effects Liver Cirrhosis - chemically induced Liver Cirrhosis - pathology Macrophages - ultrastructure Male Monocytes - ultrastructure Organ Specificity Phagocytosis Pulmonary Artery - drug effects Rats Rats, Inbred Strains |
| title | Systemic histopathology of rats with CCl4-induced hepatic cirrhosis |
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