Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation

When cultured human keratinocytes reach confluence, they undergo a program of changes replicating features of differentiation in vivo, including exit from the proliferative pool, increased cell size, and expression of specialized differentiation marker proteins. Previously, we showed that insulin is...

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Veröffentlicht in:	Molecular carcinogenesis 2010-04, Vol.49 (4), p.398
Hauptverfasser:	Reznikova, Tatiana V, Phillips, Marjorie A, Patterson, Timothy J, Rice, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenites - pharmacology Cell Differentiation - drug effects Cell Line, Transformed Cell Proliferation - drug effects Cell Size - drug effects Humans Hypoglycemic Agents - pharmacology Insulin - pharmacology Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Protein Kinase C-delta - metabolism RNA, Messenger - analysis Signal Transduction - physiology
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