Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis

A single nucleotide polymorphism in the DAB2IP gene is associated with risk of aggressive prostate cancer (PCa), and loss of DAB2IP expression is frequently detected in metastatic PCa. However, the functional role of DAB2IP in PCa remains unknown. Here, we show that the loss of DAB2IP expression ini...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-02, Vol.107 (6), p.2485-2490
Hauptverfasser:	Xie, Daxing, Gore, Crystal, Liu, Jun, Pong, Rey-Chen, Mason, Ralph, Hao, Guiyang, Long, Michael, Kabbani, Wareef, Yu, Luyang, Zhang, Haifeng, Chen, Hong, Sun, Xiankai, Boothman, David A, Min, Wang, Hsieh, Jer-Tsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Biological Sciences Blotting, Western Cadherins Cadherins - genetics Cadherins - metabolism Cancer Cell Line Cell Line, Tumor Cell lines Cell Movement Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Gene Expression Genes HEK293 cells Humans Immunohistochemistry Male Mesoderm - metabolism Mesoderm - pathology Metastasis Mice Mice, Nude Neoplasm Metastasis Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oncology Phosphorylation Polymorphism Prostate Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism ras GTPase-Activating Proteins - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - genetics Rodents TCF Transcription Factors - metabolism Transfection Transplantation, Heterologous Tumors Vimentin - genetics Vimentin - metabolism
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