RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia

Pancreatic cancer is one of the most lethal malignancies. To discover functionally relevant modulators of pancreatic neoplasia, we performed activity-based proteomic profiling on primary human ductal adenocarcinomas. Here, we identify retinoblastoma-binding protein 9 (RBBP9) as a tumor-associated se...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-02, Vol.107 (5), p.2189-2194
Hauptverfasser:	Shields, David J, Niessen, Sherry, Murphy, Eric A, Mielgo, Ainhoa, Desgrosellier, Jay S, Lau, Steven K.M, Barnes, Leo A, Lesperance, Jacqueline, Bouvet, Michael, Tarin, David, Cravatt, Benjamin F, Cheresh, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological Sciences Cadherins Cadherins - metabolism Cancer Carcinogenesis Carcinoma, Pancreatic Ductal - enzymology Carcinoma, Pancreatic Ductal - etiology Carcinoma, Pancreatic Ductal - pathology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell growth Cell Line, Tumor Cell lines Cells Enzymes Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Mice, Nude Molecular Sequence Data Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Pancreatic cancer Pancreatic cells Pancreatic neoplasms Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - etiology Pancreatic Neoplasms - pathology Phosphorylation Proteins Proteomics Sequence Homology, Amino Acid Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction Smad2 Protein - metabolism Smad3 Protein - metabolism Transforming Growth Factor beta - metabolism Tumor cell line Tumors
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