Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin

Glycosaminoglycans (GAGs), in particular as part of heparan sulfate proteoglycans, are associated with cerebral amyloid angiopathy (CAA). Similarly, GAGs are also associated with the severe CAA found in patients suffering from hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-...

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Veröffentlicht in:	Neuroscience research 2010-04, Vol.66 (4), p.380
Hauptverfasser:	Timmer, Nienke M, Schirris, Tom J J, Bruinsma, Ilona B, Otte-Höller, Irene, van Kuppevelt, Toin H, de Waal, Robert M W, Verbeek, Marcel M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - pathology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - pharmacology Amyloid beta-Peptides - physiology Cell Death - drug effects Cells, Cultured Cerebral Amyloid Angiopathy - pathology Chondroitin Sulfates - physiology Female Heparin - physiology Heparitin Sulfate - physiology Humans Mutation Occipital Lobe - blood supply Occipital Lobe - pathology Peptide Fragments - genetics Peptide Fragments - pharmacology Peptide Fragments - physiology Pericytes - drug effects Pericytes - pathology
Online-Zugang:	Volltext
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