Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta

Diacylglycerol kinases (DGKs) are key regulators of diacylglycerol-dependent signaling pathways. Among the 10 DGK isoforms, DGK-zeta is the only nuclear form that contains a nuclear localization signal. Here, by site-directed mutagenesis, we showed that DGK-zeta also displays a functional independen...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2010-01, Vol.9 (2), p.384
Hauptverfasser:	Evangelisti, Camilla, Gaboardi, Gian Carlo, Billi, Anna Maria, Ognibene, Andrea, Goto, Kaoru, Tazzari, Pier Luigi, McCubrey, James A, Martelli, Alberto M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibiotics, Antineoplastic - pharmacology Cell Nucleus - enzymology Diacylglycerol Kinase - chemistry Diacylglycerol Kinase - genetics Diacylglycerol Kinase - metabolism Exportin 1 Protein Fatty Acids, Unsaturated - pharmacology G1 Phase Karyopherins - metabolism Mice Molecular Sequence Data Mutagenesis, Site-Directed Nuclear Export Signals - genetics Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Resting Phase, Cell Cycle Signal Transduction
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