Beneficial Effect of Phosphodiesterase-5 Inhibitor in Experimental Inflammatory Bowel Disease; Molecular Evidence for Involvement of Oxidative Stress

ABSTRACT Inflammatory bowel disease (IBD) is a common and chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. Reactive oxygen metabolites (ROMs) play a pathogenic role in IBD. We aimed to examine the protective effect of sildenafil, a cGMP phosphodie...

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Veröffentlicht in:	Toxicology mechanisms and methods 2007-01, Vol.17 (5), p.281-288
Hauptverfasser:	Khoshakhlagh, Pooneh, Bahrololoumi-Shapourabadi, Mina, Mohammadirad, Azadeh, Ashtaral-Nakhai, Leila, Minaie, Bagher, Abdollahi, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Inflammatory Bowel Disease Lipid Peroxidation Molecular Mechanism Myeloperoxidase Oxidative Stress Phosphodiesterase Inhibitors Sildenafil
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