Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis

pH homeostasis is essential for life, yet it remains unclear how animals sense their systemic acid/base (A/B) status. Soluble adenylyl cyclase (sAC) is an evolutionary conserved signaling enzyme that produces the second messenger cAMP in response to bicarbonate ions (HCO₃⁻). We cloned the sAC orthol...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-01, Vol.107 (1), p.442-447
Hauptverfasser:	Tresguerres, Martin, Parks, Scott K, Salazar, Eric, Levin, Lonny R, Goss, Greg G, Buck, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium - physiology Adenylyl Cyclase Inhibitors Adenylyl Cyclases - classification Adenylyl Cyclases - genetics Adenylyl Cyclases - metabolism Alkalosis Alkalosis - metabolism Animals Bicarbonates Bicarbonates - metabolism Biological Sciences Blood Cells Chemical bases Dogfish Enzymes Gills Gills - enzymology Homeostasis Humans Hydrogen-Ion Concentration Ions Kidney cells Molecular Sequence Data Molecules Phylogeny Physiological regulation Protons Sensors Sharks
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