Tumor suppression by ARF: Gatekeeper and caretaker

ARF is a vital tumor suppressor and its loss contributes significantly to cancer. The frequency in which ARF is mutated, deleted or silenced is second to the loss of p53. The most documented and widely accepted activity of ARF is mediated through its activation of the p53 transcriptional program by...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2010-01, Vol.9 (1), p.86-89
Hauptverfasser:	Dominguez-Brauer, Carmen, Brauer, Patrick M., Chen, Yi-Ju, Pimkina, Julia, Raychaudhuri, Pradip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Biology Bioscience Calcium Cancer Cell Cycle Cyclin-Dependent Kinase Inhibitor p16 - metabolism E2F Transcription Factors - metabolism Humans Landes Models, Biological Neoplasms - metabolism Neoplasms - pathology Organogenesis Protein Binding - physiology Proteins Signal Transduction - genetics Signal Transduction - physiology Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
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