Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3

During early cardiac development, the progenitor cells of the heart valves and membranous septa undergo an epithelial-mesenchymal transformation. Previous studies have shown that this transformation depends on the activity of a transforming growth factor beta (TGF beta) molecule produced by the hear...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-02, Vol.88 (4), p.1516-1520
Hauptverfasser:	Potts, J D, Dagle, J M, Walder, J A, Weeks, D L, Runyan, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Differentiation - drug effects Chick Embryo Endothelium - cytology Epithelial Cells Heart - embryology Molecular Sequence Data Myocardium - cytology Oligonucleotides, Antisense - pharmacology RNA Probes RNA, Messenger - analysis RNA, Messenger - genetics Transforming Growth Factor beta - genetics Transforming Growth Factor beta - physiology
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