Spinal Cord Compression And Extramedullary Hematopoiesis in Young Egyptian β-thalassemia Patients
The problem of spinal cord compression (SCC) related to extramedullary hematopoiesis (EMH) in β-thalassemia (β-thal) patients, both clinically and radiologically and its correlation with laboratory parameters of anemia and hemosiderosis was assessed. Sixty β-thal patients were included and divided i...
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| Veröffentlicht in: | Hemoglobin 2009-12, Vol.33 (6), p.448-462 |
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| creator | Tantawy, Azza A.G. Adly, Amira A.M. Mahdy, Sameh A.R. Kamel, Ghada Z. |
| description | The problem of spinal cord compression (SCC) related to extramedullary hematopoiesis (EMH) in β-thalassemia (β-thal) patients, both clinically and radiologically and its correlation with laboratory parameters of anemia and hemosiderosis was assessed. Sixty β-thal patients were included and divided into group I: 40 β-thal major patients (β-TM), aged 7-30 years with a mean age of 15 ± 5.3 years, group II: 20 β-thal intermedia patients (β-TI) aged 6-20 years with a mean age of 13 ± 4.6 years. They were subjected to neurological examination, thoracic and lumbosacral computed tomography (CT) and magnetic resonance imaging (MRI). Spinal EMH was found in 13.3% of the thalassemic patients with a higher incidence in β-TI compared to β-TM patients (p = 0.03). Evidence of spinal EMH was associated with higher serum ferritin (p < 0.0001), lower pre transfusion hemoglobin (Hb) (p = 0.002) and lower transfusion index (p = 0.01). Extramedullary hematopoiesis was more evident in young β-TI patients, and was related to inadequate chelation, high serum ferritin and inadequate transfusion therapy. |
| doi_str_mv | 10.3109/03630260903337451 |
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Sixty β-thal patients were included and divided into group I: 40 β-thal major patients (β-TM), aged 7-30 years with a mean age of 15 ± 5.3 years, group II: 20 β-thal intermedia patients (β-TI) aged 6-20 years with a mean age of 13 ± 4.6 years. They were subjected to neurological examination, thoracic and lumbosacral computed tomography (CT) and magnetic resonance imaging (MRI). Spinal EMH was found in 13.3% of the thalassemic patients with a higher incidence in β-TI compared to β-TM patients (p = 0.03). Evidence of spinal EMH was associated with higher serum ferritin (p < 0.0001), lower pre transfusion hemoglobin (Hb) (p = 0.002) and lower transfusion index (p = 0.01). Extramedullary hematopoiesis was more evident in young β-TI patients, and was related to inadequate chelation, high serum ferritin and inadequate transfusion therapy.</description><identifier>ISSN: 0363-0269</identifier><identifier>EISSN: 1532-432X</identifier><identifier>DOI: 10.3109/03630260903337451</identifier><identifier>PMID: 19958190</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adolescent ; Adult ; Anemia - etiology ; beta-Thalassemia - complications ; Blood Transfusion ; Child ; Computed tomography (CT) ; Extramedullary hematopoiesis (EMH) ; Ferritins - blood ; Hematopoiesis, Extramedullary ; Hemoglobins - analysis ; Hemosiderosis - etiology ; Humans ; Magnetic Resonance Imaging ; Magnetic resonance imaging (MRI) ; Spinal cord compression (SCC) ; Spinal Cord Compression - diagnosis ; Spinal Cord Compression - etiology ; Tomography, X-Ray Computed ; Young Adult ; β-Thalassemia (β-thal)</subject><ispartof>Hemoglobin, 2009-12, Vol.33 (6), p.448-462</ispartof><rights>Informa UK Ltd. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-3fb50eb7cf45ae016cad8c5f481ad8b3b9ed16a6096f9ff253b8bd0120f041a13</citedby><cites>FETCH-LOGICAL-c405t-3fb50eb7cf45ae016cad8c5f481ad8b3b9ed16a6096f9ff253b8bd0120f041a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03630260903337451$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03630260903337451$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19958190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tantawy, Azza A.G.</creatorcontrib><creatorcontrib>Adly, Amira A.M.</creatorcontrib><creatorcontrib>Mahdy, Sameh A.R.</creatorcontrib><creatorcontrib>Kamel, Ghada Z.</creatorcontrib><title>Spinal Cord Compression And Extramedullary Hematopoiesis in Young Egyptian β-thalassemia Patients</title><title>Hemoglobin</title><addtitle>Hemoglobin</addtitle><description>The problem of spinal cord compression (SCC) related to extramedullary hematopoiesis (EMH) in β-thalassemia (β-thal) patients, both clinically and radiologically and its correlation with laboratory parameters of anemia and hemosiderosis was assessed. Sixty β-thal patients were included and divided into group I: 40 β-thal major patients (β-TM), aged 7-30 years with a mean age of 15 ± 5.3 years, group II: 20 β-thal intermedia patients (β-TI) aged 6-20 years with a mean age of 13 ± 4.6 years. They were subjected to neurological examination, thoracic and lumbosacral computed tomography (CT) and magnetic resonance imaging (MRI). Spinal EMH was found in 13.3% of the thalassemic patients with a higher incidence in β-TI compared to β-TM patients (p = 0.03). Evidence of spinal EMH was associated with higher serum ferritin (p < 0.0001), lower pre transfusion hemoglobin (Hb) (p = 0.002) and lower transfusion index (p = 0.01). Extramedullary hematopoiesis was more evident in young β-TI patients, and was related to inadequate chelation, high serum ferritin and inadequate transfusion therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia - etiology</subject><subject>beta-Thalassemia - complications</subject><subject>Blood Transfusion</subject><subject>Child</subject><subject>Computed tomography (CT)</subject><subject>Extramedullary hematopoiesis (EMH)</subject><subject>Ferritins - blood</subject><subject>Hematopoiesis, Extramedullary</subject><subject>Hemoglobins - analysis</subject><subject>Hemosiderosis - etiology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic resonance imaging (MRI)</subject><subject>Spinal cord compression (SCC)</subject><subject>Spinal Cord Compression - diagnosis</subject><subject>Spinal Cord Compression - etiology</subject><subject>Tomography, X-Ray Computed</subject><subject>Young Adult</subject><subject>β-Thalassemia (β-thal)</subject><issn>0363-0269</issn><issn>1532-432X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGKFDEQhoMo7rj6AF4kN0_tVjqdng56WYbRFRYUVNBTU92d7GTpTtpUmt15LR_EZzLDDIiIXlKB-v6fqr8Yey7glRSgL0DWEsoaNEgp15USD9hKKFkWlSy_PmSrQ7_IgD5jT4huAYReQ_WYnQmtVSM0rFj3aXYeR74JccjPNEdD5ILnl37g2_sUcTLDMo4Y9_zKTJjCHJwhR9x5_i0s_oZvb_Zzcuj5zx9F2uGIRGZyyD9icsYnesoeWRzJPDvVc_bl7fbz5qq4_vDu_ebyuugrUKmQtlNgunVvK4UGRN3j0PTKVo3In0522gyixrxtbbW1pZJd0w0gSrBQCRTynL08-s4xfF8MpXZy1Js8uzdhoXYtZa0b3ahMiiPZx0AUjW3n6Ka8YiugPSTb_pVs1rw4uS9djuS34hRlBt4cAedtiBPehTgObcL9GKKN6HtHB-9_-7_-Q74zOKZdj9G0t2GJ-Ub0n-l-AaX5mzU</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Tantawy, Azza A.G.</creator><creator>Adly, Amira A.M.</creator><creator>Mahdy, Sameh A.R.</creator><creator>Kamel, Ghada Z.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Spinal Cord Compression And Extramedullary Hematopoiesis in Young Egyptian β-thalassemia Patients</title><author>Tantawy, Azza A.G. ; Adly, Amira A.M. ; Mahdy, Sameh A.R. ; Kamel, Ghada Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-3fb50eb7cf45ae016cad8c5f481ad8b3b9ed16a6096f9ff253b8bd0120f041a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia - etiology</topic><topic>beta-Thalassemia - complications</topic><topic>Blood Transfusion</topic><topic>Child</topic><topic>Computed tomography (CT)</topic><topic>Extramedullary hematopoiesis (EMH)</topic><topic>Ferritins - blood</topic><topic>Hematopoiesis, Extramedullary</topic><topic>Hemoglobins - analysis</topic><topic>Hemosiderosis - etiology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic resonance imaging (MRI)</topic><topic>Spinal cord compression (SCC)</topic><topic>Spinal Cord Compression - diagnosis</topic><topic>Spinal Cord Compression - etiology</topic><topic>Tomography, X-Ray Computed</topic><topic>Young Adult</topic><topic>β-Thalassemia (β-thal)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tantawy, Azza A.G.</creatorcontrib><creatorcontrib>Adly, Amira A.M.</creatorcontrib><creatorcontrib>Mahdy, Sameh A.R.</creatorcontrib><creatorcontrib>Kamel, Ghada Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hemoglobin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tantawy, Azza A.G.</au><au>Adly, Amira A.M.</au><au>Mahdy, Sameh A.R.</au><au>Kamel, Ghada Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinal Cord Compression And Extramedullary Hematopoiesis in Young Egyptian β-thalassemia Patients</atitle><jtitle>Hemoglobin</jtitle><addtitle>Hemoglobin</addtitle><date>2009-12</date><risdate>2009</risdate><volume>33</volume><issue>6</issue><spage>448</spage><epage>462</epage><pages>448-462</pages><issn>0363-0269</issn><eissn>1532-432X</eissn><abstract>The problem of spinal cord compression (SCC) related to extramedullary hematopoiesis (EMH) in β-thalassemia (β-thal) patients, both clinically and radiologically and its correlation with laboratory parameters of anemia and hemosiderosis was assessed. Sixty β-thal patients were included and divided into group I: 40 β-thal major patients (β-TM), aged 7-30 years with a mean age of 15 ± 5.3 years, group II: 20 β-thal intermedia patients (β-TI) aged 6-20 years with a mean age of 13 ± 4.6 years. They were subjected to neurological examination, thoracic and lumbosacral computed tomography (CT) and magnetic resonance imaging (MRI). Spinal EMH was found in 13.3% of the thalassemic patients with a higher incidence in β-TI compared to β-TM patients (p = 0.03). Evidence of spinal EMH was associated with higher serum ferritin (p < 0.0001), lower pre transfusion hemoglobin (Hb) (p = 0.002) and lower transfusion index (p = 0.01). Extramedullary hematopoiesis was more evident in young β-TI patients, and was related to inadequate chelation, high serum ferritin and inadequate transfusion therapy.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19958190</pmid><doi>10.3109/03630260903337451</doi><tpages>15</tpages></addata></record> |
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| subjects | Adolescent Adult Anemia - etiology beta-Thalassemia - complications Blood Transfusion Child Computed tomography (CT) Extramedullary hematopoiesis (EMH) Ferritins - blood Hematopoiesis, Extramedullary Hemoglobins - analysis Hemosiderosis - etiology Humans Magnetic Resonance Imaging Magnetic resonance imaging (MRI) Spinal cord compression (SCC) Spinal Cord Compression - diagnosis Spinal Cord Compression - etiology Tomography, X-Ray Computed Young Adult β-Thalassemia (β-thal) |
| title | Spinal Cord Compression And Extramedullary Hematopoiesis in Young Egyptian β-thalassemia Patients |
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