In vivo evaluation of a new sustained-release formulation of morphine

The pharmacokinetics of a novel sustained-release oral formulation of morphine have been evaluated. The formulation consisted of tablets containing a morphine-Eudragit®L complex (MEC) which had shown good sustained-release properties in previous in vitro dissolution studies. MEC tablets were adminis...

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Veröffentlicht in:	Pharmazie 2009-10, Vol.64 (10), p.653-655
Hauptverfasser:	Araico, A., Saadeddin, A., Torres-Molina, F., Peris, J.-E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - chemistry Analgesics, Opioid - pharmacokinetics Animals Area Under Curve Chromatography, High Pressure Liquid Delayed-Action Preparations Dogs Excipients Female Half-Life Male Morphine - administration & dosage Morphine - chemistry Morphine - pharmacokinetics Polymethacrylic Acids Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
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