4-aminobiphenyl hemoglobin adducts in fetuses exposed to the tobacco smoke carcinogen in utero

Maternal-fetal exchange of a potent tobacco-related human carcinogen, 4-aminobiphenyl, was studied in smoking (n = 14) and nonsmoking (n = 38) pregnant women. N-Hydroxy-4-aminobiphenyl, the active metabolite of 4-aminobiphenyl, forms chemical addition products (adducts) with hemoglobin. Levels of 4-...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1991-02, Vol.83 (4), p.274-280
Hauptverfasser:	COGHLIN, J, GANN, P. H, HAMMOND, S. K, SKIPPER, P. L, TAGHIZADEH, K, PAUL, M, TANNENBAUM, S. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobiphenyl Compounds - blood Aminobiphenyl Compounds - metabolism Aminobiphenyl Compounds - pharmacokinetics Biological and medical sciences Carcinogens - metabolism Carcinogens - pharmacokinetics Dose-Response Relationship, Drug Female Fetus - metabolism Hemoglobins - metabolism Humans Maternal-Fetal Exchange Medical sciences Nicotiana Plants, Toxic Pregnancy - blood Prenatal Exposure Delayed Effects Smoke - adverse effects Tobacco, tobacco smoking Toxicology
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