EARLY SUBCUTANEOUS ADMINISTRATION OF ETANERCEPT (ENBREL) PREVENTS FROM HYPEROXIA-INDUCED LUNG INJURY

Both hyperoxia-induced proapoptotic sensitization of alveolar type II cells (TII cells) and high-stretch mechanical ventilation induced pulmonary inflammation are tumor necrosis factor alpha (TNFα) mediated. Therefore, binding of free TNFα should protect from TNFα-mediated acute lung injury and amel...

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Veröffentlicht in:	Experimental lung research 2009-11, Vol.35 (9), p.770-780
Hauptverfasser:	Guthmann, Florian, Wissel, Heide, Rüstow, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal apoptosis Capillary Permeability Caspase 3 - metabolism Etanercept Granulocytes hyperoxia Hyperoxia - complications Immunoglobulin G - administration & dosage Immunoglobulin G - pharmacology Immunoglobulin G - therapeutic use lung lung injury Lung Injury - prevention & control Pulmonary Alveoli - blood supply rat Rats Receptors, Tumor Necrosis Factor - administration & dosage Receptors, Tumor Necrosis Factor - antagonists & inhibitors Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - therapeutic use TNFα Transcriptional Activation - drug effects Tumor Necrosis Factor-alpha
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