Development and characterization of a melphalan-resistant human multiple myeloma cell line

We present data describing a human myeloma cell line (8226/LR-5) selected for resistance to melphalan which exhibits a 7-fold level of resistance to melphalan and is partially cross-resistant to other bifunctional alkylators and X-irradiation. Melphalan resistance is relatively unstable with a decre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1991-02, Vol.51 (3), p.995-1002
Hauptverfasser:	BELLAMY, W. T, DALTON, W. S, GLEASON, M. C, GROGAN, T. M, TRENT, J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - metabolism Antineoplastic agents Biological and medical sciences Buthionine Sulfoximine Cell Survival DNA, Neoplasm - analysis Drug Resistance General aspects Glutathione - metabolism Humans Karyotyping Medical sciences Melphalan - metabolism Methionine Sulfoximine - analogs & derivatives Methionine Sulfoximine - metabolism Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology Myeloma Proteins - analysis Pharmacology. Drug treatments Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology Tumor Cells, Cultured - radiation effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!