Actin filament nucleation and elongation factors - structure-function relationships

The spontaneous and unregulated polymerization of actin filaments is inhibited in cells by actin monomer-binding proteins such as profilin and Tβ4. Eukaryotic cells and certain pathogens use filament nucleators to stabilize actin polymerization nuclei, whose formation is rate-limiting. Known filamen...

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Veröffentlicht in:	Critical reviews in biochemistry and molecular biology 2009-12, Vol.44 (6), p.351-366
1. Verfasser:	Dominguez, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - chemistry Actin Cytoskeleton - metabolism Actin filament Animals Arp2/3 complex Cobl Eva/VASP Humans Lmod Microfilament Proteins - chemistry Microfilament Proteins - metabolism Models, Biological nucleation and elongation Protein Conformation Protein Multimerization Spire VopL/VopF
Online-Zugang:	Volltext
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