Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neuro...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2009-11, Vol.7 (22), p.4695 |
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| container_issue | 22 |
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| container_title | Organic & biomolecular chemistry |
| container_volume | 7 |
| creator | Van Ryssen, Michael P Avlonitis, Nicolaos Giniatullin, Rashid McDougall, Craig Carr, James L Stanton-Humphreys, Megan N Borgström, Emma L A Brown, C Tom A Fayuk, Dmitriy Surin, Alexander Niittykoski, Minna Khiroug, Leonard Conway, Stuart J |
| description | The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors. |
| doi_str_mv | 10.1039/b914981c |
| format | Article |
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The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. 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The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Capsaicin - analogs & derivatives</subject><subject>Capsaicin - chemical synthesis</subject><subject>Capsaicin - chemistry</subject><subject>Capsaicin - pharmacology</subject><subject>Halogenation - drug effects</subject><subject>Intracellular Space - drug effects</subject><subject>Intracellular Space - metabolism</subject><subject>Intracellular Space - radiation effects</subject><subject>Lasers</subject><subject>Ligands</subject><subject>Light</subject><subject>Membrane Potentials - drug effects</subject><subject>Photolysis - drug effects</subject><subject>Photolysis - radiation effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Trigeminal Nerve - cytology</subject><subject>Trigeminal Nerve - drug effects</subject><subject>Trigeminal Nerve - radiation effects</subject><subject>TRPV Cation Channels - agonists</subject><subject>TRPV Cation Channels - antagonists & inhibitors</subject><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T1FLwzAYDIK4OQV_geQHWM2XtEnzKEOnMFB0-lq-NMkW6drSZEL_vUrd091x3HFHyBWwW2BC3xkNuS6hPiFzyJXKWCH0jJzH-MUYaCXzMzIDXcpCMTUn1fvYpp2LId7Qftelrhl_OY3pYIOLFFtLQ0u_Qxq6yR9c4zA62nla49ZZunl7_QSK264NMU0JbNNRX5BTj010l_-4IB-PD5vlU7Z-WT0v79dZD6xMmRYS0XDuAf5GcldqnlvrDCtrIYVlnEt0hUQrVGGNN4U3UlkvUHKPPhcLcj319gezd7bqh7DHYayOT8UPTvJUMQ</recordid><startdate>20091121</startdate><enddate>20091121</enddate><creator>Van Ryssen, Michael P</creator><creator>Avlonitis, Nicolaos</creator><creator>Giniatullin, Rashid</creator><creator>McDougall, Craig</creator><creator>Carr, James L</creator><creator>Stanton-Humphreys, Megan N</creator><creator>Borgström, Emma L A</creator><creator>Brown, C Tom A</creator><creator>Fayuk, Dmitriy</creator><creator>Surin, Alexander</creator><creator>Niittykoski, Minna</creator><creator>Khiroug, Leonard</creator><creator>Conway, Stuart J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20091121</creationdate><title>Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists</title><author>Van Ryssen, Michael P ; 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The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.</abstract><cop>England</cop><pmid>19865707</pmid><doi>10.1039/b914981c</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1477-0539 |
| ispartof | Organic & biomolecular chemistry, 2009-11, Vol.7 (22), p.4695 |
| issn | 1477-0539 |
| language | eng |
| recordid | cdi_pubmed_primary_19865707 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Calcium - metabolism Capsaicin - analogs & derivatives Capsaicin - chemical synthesis Capsaicin - chemistry Capsaicin - pharmacology Halogenation - drug effects Intracellular Space - drug effects Intracellular Space - metabolism Intracellular Space - radiation effects Lasers Ligands Light Membrane Potentials - drug effects Photolysis - drug effects Photolysis - radiation effects Rats Rats, Wistar Trigeminal Nerve - cytology Trigeminal Nerve - drug effects Trigeminal Nerve - radiation effects TRPV Cation Channels - agonists TRPV Cation Channels - antagonists & inhibitors |
| title | Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists |
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