Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neuro...

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Veröffentlicht in:	Organic & biomolecular chemistry 2009-11, Vol.7 (22), p.4695
Hauptverfasser:	Van Ryssen, Michael P, Avlonitis, Nicolaos, Giniatullin, Rashid, McDougall, Craig, Carr, James L, Stanton-Humphreys, Megan N, Borgström, Emma L A, Brown, C Tom A, Fayuk, Dmitriy, Surin, Alexander, Niittykoski, Minna, Khiroug, Leonard, Conway, Stuart J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Capsaicin - analogs & derivatives Capsaicin - chemical synthesis Capsaicin - chemistry Capsaicin - pharmacology Halogenation - drug effects Intracellular Space - drug effects Intracellular Space - metabolism Intracellular Space - radiation effects Lasers Ligands Light Membrane Potentials - drug effects Photolysis - drug effects Photolysis - radiation effects Rats Rats, Wistar Trigeminal Nerve - cytology Trigeminal Nerve - drug effects Trigeminal Nerve - radiation effects TRPV Cation Channels - agonists TRPV Cation Channels - antagonists & inhibitors
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Zusammenfassung:	The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
ISSN:	1477-0539
DOI:	10.1039/b914981c