The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}

The IGF-I receptor (IGF-IR) was identified as a tumor progression factor, but its role in invasion and metastasis has been the subject of some controversy. Previously we reported that in murine lung carcinoma M-27 cells, overexpression of IGF-IR increased the synthesis and activation of matrix metal...

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Veröffentlicht in:Molecular endocrinology (Baltimore, Md.) Md.), 2009-12, Vol.23 (12), p.2013
Hauptverfasser: Li, Shun, Zhang, Donglei, Yang, Long, Burnier, Julia V, Wang, Ni, Lin, Rongtuan, Lee, Eunice R, Glazer, Robert I, Brodt, Pnina
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Sprache:eng
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