Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

1 Department of Physiology & Biophysics, University of Washington, Seattle, Washington; and 2 Children's Hospital Medical Center for Molecular Cardiovascular Biology, Cincinnati, Ohio Submitted 22 June 2009 ; accepted in final form 13 October 2009 Ca + sparklets are subcellular Ca 2+ signal...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2010-02, Vol.298 (2), p.C211-C220
Hauptverfasser:	Navedo, Manuel F, Takeda, Yukari, Nieves-Cintron, Madeline, Molkentin, Jeffery D, Santana, Luis F
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins - metabolism Animals Blood Glucose - metabolism Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Calcium Signaling - drug effects Cerebral Arteries - metabolism Colforsin - pharmacology Cyclic AMP-Dependent Protein Kinases - metabolism Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - metabolism Diabetic Angiopathies - physiopathology Disease Models, Animal Enzyme Activation Enzyme Activators - pharmacology Hyperglycemia - complications Hyperglycemia - metabolism Hyperglycemia - physiopathology Intracellular Signaling Peptides and Proteins - pharmacology Membrane Potentials Mice Mice, Knockout Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiopathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Protein Kinase Inhibitors - pharmacology Proteins - pharmacology Rats Rats, Sprague-Dawley Signal Transduction Time Factors Up-Regulation Vascular Biology
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