Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis
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Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2010-01, Vol.54 (1), p.103-108 |
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creator | SAFI, Hassan FLEISCHMANN, Robert D PETERSON, Scott N JONES, Marcus B JARRAHI, Behnam ALLAND, David |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01288-09</identifier><identifier>PMID: 19822701</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Alleles ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antitubercular Agents ; Antitubercular Agents - pharmacology ; Biological and medical sciences ; Codon ; DNA Primers ; DNA, Bacterial - genetics ; Drug Resistance, Bacterial - genetics ; Ethambutol ; Ethambutol - pharmacology ; Genes, Bacterial ; Genes, Bacterial - genetics ; Mechanisms of Resistance ; Medical sciences ; Microbial Sensitivity Tests ; Mutation ; Mutation - genetics ; Mycobacterium ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - genetics ; Operon ; Pentosyltransferases ; Pentosyltransferases - genetics ; Pharmacology. Drug treatments ; Plasmids - genetics ; Rifampin - pharmacology</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2010-01, Vol.54 (1), p.103-108</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 American Society for Microbiology</rights><rights>Copyright © 2010, American Society for Microbiology 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a503t-a0b0373c8657226dc980d1cb7661a7769575493d4333d0d7a308bc3851244ad83</citedby><cites>FETCH-LOGICAL-a503t-a0b0373c8657226dc980d1cb7661a7769575493d4333d0d7a308bc3851244ad83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798522/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798522/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22515753$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19822701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAFI, Hassan</creatorcontrib><creatorcontrib>FLEISCHMANN, Robert D</creatorcontrib><creatorcontrib>PETERSON, Scott N</creatorcontrib><creatorcontrib>JONES, Marcus B</creatorcontrib><creatorcontrib>JARRAHI, Behnam</creatorcontrib><creatorcontrib>ALLAND, David</creatorcontrib><title>Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Alleles</subject><subject>Antibiotics. Antiinfectious agents. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>19822701</pmid><doi>10.1128/AAC.01288-09</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
subjects | Alleles Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents Antitubercular Agents - pharmacology Biological and medical sciences Codon DNA Primers DNA, Bacterial - genetics Drug Resistance, Bacterial - genetics Ethambutol Ethambutol - pharmacology Genes, Bacterial Genes, Bacterial - genetics Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests Mutation Mutation - genetics Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Operon Pentosyltransferases Pentosyltransferases - genetics Pharmacology. Drug treatments Plasmids - genetics Rifampin - pharmacology |
title | Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis |
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