Synthesis and Evaluation of Stable Bidentate Transition Metal Complexes of 1-(Chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as Hypoxia Selective Cytotoxins

A series of metal complexes were prepared as potential prodrugs of the extremely toxic DNA minor groove alkylator 1-(chloromethyl)-5-hydroxy-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) and close analogues. The pyrrolo[3,2-f]quinoline cytotoxins...

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Veröffentlicht in:	Journal of medicinal chemistry 2009-11, Vol.52 (21), p.6822-6834
Hauptverfasser:	Milbank, Jared B. J, Stevenson, Ralph J, Ware, David C, Chang, John Y. C, Tercel, Moana, Ahn, G-One, Wilson, William R, Denny, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Alkylating - chemical synthesis Antineoplastic Agents, Alkylating - pharmacology Antineoplastic Agents, Alkylating - radiation effects Biological and medical sciences Cell Hypoxia Cell Line, Tumor Chelating Agents - chemical synthesis Chelating Agents - chemistry Cobalt Coordination Complexes - chemical synthesis Coordination Complexes - pharmacology Coordination Complexes - radiation effects Drug Screening Assays, Antitumor General aspects Humans Indoles - chemical synthesis Indoles - pharmacology Indoles - radiation effects Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - pharmacology Prodrugs - radiation effects Pyrroles - chemical synthesis Pyrroles - pharmacology Pyrroles - radiation effects Quinolines - chemical synthesis Quinolines - pharmacology Quinolines - radiation effects Radiation, Ionizing Stereoisomerism Structure-Activity Relationship
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