Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells
Down-regulation of let-7 microRNA (miRNA) is a key event in lung cancer. Despite recent advances in survival signaling, the roles of let-7 in the context of lung cancer are not fully clear. In this study, we showed that let-7a, a member of let-7 family, negatively regulated the expression of NIRF th...
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| Veröffentlicht in: | FEBS letters 2009-11, Vol.583 (21), p.3501 |
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| creator | He, Xiaoyan Duan, Changzhu Chen, Junxia Ou-Yang, Xi Zhang, Zheng Li, Chunlei Peng, Huimin |
| description | Down-regulation of let-7 microRNA (miRNA) is a key event in lung cancer. Despite recent advances in survival signaling, the roles of let-7 in the context of lung cancer are not fully clear. In this study, we showed that let-7a, a member of let-7 family, negatively regulated the expression of NIRF through NIRF 3' UTR. We also showed that NIRF was required for the let-7a-mediated elevation of p21(WAF1). These findings suggest that growth-inhibitory effect of let-7a on the A549 cells in vitro and in vivo may be explained in part by le-7a-induced suppression of NIRF and elevation of p21(WAF1). This work reveals a novel regulatory mechanism for let-7a in the control of cellular proliferation and lung carcinogenesis. |
| doi_str_mv | 10.1016/j.febslet.2009.10.007 |
| format | Article |
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Despite recent advances in survival signaling, the roles of let-7 in the context of lung cancer are not fully clear. In this study, we showed that let-7a, a member of let-7 family, negatively regulated the expression of NIRF through NIRF 3' UTR. We also showed that NIRF was required for the let-7a-mediated elevation of p21(WAF1). These findings suggest that growth-inhibitory effect of let-7a on the A549 cells in vitro and in vivo may be explained in part by le-7a-induced suppression of NIRF and elevation of p21(WAF1). This work reveals a novel regulatory mechanism for let-7a in the control of cellular proliferation and lung carcinogenesis.</description><subject>3' Untranslated Regions - genetics</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Cell Transformation, Neoplastic</subject><subject>Computational Biology</subject><subject>Conserved Sequence</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - genetics</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</subject><subject>Down-Regulation - genetics</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Phylogeny</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T99LwzAQDoK4Of0TlDzqQ-td2yTN4xhWB0NBFB9Hml67jWwrTebYf29E5R7u4_txH8fYDUKKgPJhk7ZUe0chzQB05FIAdcbGWKo8yQtZjtil9xsAwBL1BRuhLqOmxJitFxQSZTg5-jKBPO8zvPucVnjPI0PO8_rEgxk6Cutdx_ctf5m_VdzsGu4PfT-Q9zEUVsS7YX8Mqx_HVBSau0O0W7OzNHBLzvkrdt4a5-n6b0_YR_X4PntOFq9P89l0kcRmCEmZaQmSatQoCpC2yaxsdaNANEUci1pboUDnGQhlmwhEQXmNrZZaChD5hN3-3u0P9ZaaZT-st2Y4Lf9_zr8Bp5BWmA</recordid><startdate>20091103</startdate><enddate>20091103</enddate><creator>He, Xiaoyan</creator><creator>Duan, Changzhu</creator><creator>Chen, Junxia</creator><creator>Ou-Yang, Xi</creator><creator>Zhang, Zheng</creator><creator>Li, Chunlei</creator><creator>Peng, Huimin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20091103</creationdate><title>Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells</title><author>He, Xiaoyan ; Duan, Changzhu ; Chen, Junxia ; Ou-Yang, Xi ; Zhang, Zheng ; Li, Chunlei ; Peng, Huimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p210t-829606eb1915406cd2c6f9d705d4d4dc199c570932057cd09354e3b1f96965053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Cell Transformation, Neoplastic</topic><topic>Computational Biology</topic><topic>Conserved Sequence</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - genetics</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</topic><topic>Down-Regulation - genetics</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Phylogeny</topic><topic>Ubiquitin-Protein Ligases - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Xiaoyan</creatorcontrib><creatorcontrib>Duan, Changzhu</creatorcontrib><creatorcontrib>Chen, Junxia</creatorcontrib><creatorcontrib>Ou-Yang, Xi</creatorcontrib><creatorcontrib>Zhang, Zheng</creatorcontrib><creatorcontrib>Li, Chunlei</creatorcontrib><creatorcontrib>Peng, Huimin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Xiaoyan</au><au>Duan, Changzhu</au><au>Chen, Junxia</au><au>Ou-Yang, Xi</au><au>Zhang, Zheng</au><au>Li, Chunlei</au><au>Peng, Huimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2009-11-03</date><risdate>2009</risdate><volume>583</volume><issue>21</issue><spage>3501</spage><pages>3501-</pages><eissn>1873-3468</eissn><abstract>Down-regulation of let-7 microRNA (miRNA) is a key event in lung cancer. 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| ispartof | FEBS letters, 2009-11, Vol.583 (21), p.3501 |
| issn | 1873-3468 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 3' Untranslated Regions - genetics Animals Base Sequence Binding Sites Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic Computational Biology Conserved Sequence Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Down-Regulation - genetics Gene Expression Regulation, Neoplastic - genetics Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Mice, Inbred BALB C MicroRNAs - genetics MicroRNAs - metabolism Phylogeny Ubiquitin-Protein Ligases - genetics |
| title | Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells |
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