Interleukin 1 Induces β-Endorphin Secretion via Fos and Jun in AtT-20 Pituitary Cells
Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates β-endorphin release and potentiates the effects of secretagogues in AtT-20 cells, a mouse anterior pituitary cell line. Treatment of AtT-20 cells with IL-1 induced a transient and early stimulation of mRN...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1990-10, Vol.87 (20), p.7871-7874 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Fagarasan, Mirela O. Aiello, Francesca Muegge, Katherin Durum, Scott Axelrod, Julius |
| description | Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates β-endorphin release and potentiates the effects of secretagogues in AtT-20 cells, a mouse anterior pituitary cell line. Treatment of AtT-20 cells with IL-1 induced a transient and early stimulation of mRNA expression by both immediate-early protooncogenes Fos and Jun (mouse c-fos and c-jun). The effect appeared within 30 min, and returned to basal levels after 2 hr. Desensitization of protein kinase C by phorbol ester pretreatment had no effect on the ability of IL-1 to induce Fos and Jun mRNA expression. Somatostatin, an inhibitor of cAMP and β-endorphin secretion, did not reduce the IL-1 effect on Fos and Jun mRNA expression. Addition to AtT-20 cells of antisense oligonucleotides to Fos and Jun abolished the secretion induced by IL-1. These results indicate that immediate-early signals Fos and Jun are involved in IL-1-induced β-endorphin secretion in AtT-20 cells. |
| doi_str_mv | 10.1073/pnas.87.20.7871 |
| format | Article |
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Treatment of AtT-20 cells with IL-1 induced a transient and early stimulation of mRNA expression by both immediate-early protooncogenes Fos and Jun (mouse c-fos and c-jun). The effect appeared within 30 min, and returned to basal levels after 2 hr. Desensitization of protein kinase C by phorbol ester pretreatment had no effect on the ability of IL-1 to induce Fos and Jun mRNA expression. Somatostatin, an inhibitor of cAMP and β-endorphin secretion, did not reduce the IL-1 effect on Fos and Jun mRNA expression. Addition to AtT-20 cells of antisense oligonucleotides to Fos and Jun abolished the secretion induced by IL-1. These results indicate that immediate-early signals Fos and Jun are involved in IL-1-induced β-endorphin secretion in AtT-20 cells.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.87.20.7871</identifier><identifier>PMID: 1978316</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Base Sequence ; beta-Endorphin - metabolism ; Biological and medical sciences ; Cell Line ; Cell lines ; Cells ; DNA-Binding Proteins - genetics ; Fundamental and applied biological sciences. Psychology ; Genes ; Interleukin-1 - pharmacology ; Interleukins ; Messenger RNA ; Mice ; Molecular Sequence Data ; Oligonucleotide Probes ; Oligonucleotides ; Phorbol esters ; Pituitary Gland, Anterior ; Protein hormones. Growth factors. Cytokines ; Protein Kinase C - metabolism ; Protein-Tyrosine Kinases - genetics ; Proteins ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins c-fos ; Proto-Oncogene Proteins c-jun ; Proto-Oncogenes - drug effects ; RNA ; Secretion ; Somatostatin - pharmacology ; T lymphocytes ; Transcription Factors - genetics</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (20), p.7871-7874</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-3ff95b3120e6273c6b7828ee15a0d1ea67b98c922b175b7e34b91c613215ddf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/87/20.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2355435$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2355435$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19547676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1978316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fagarasan, Mirela O.</creatorcontrib><creatorcontrib>Aiello, Francesca</creatorcontrib><creatorcontrib>Muegge, Katherin</creatorcontrib><creatorcontrib>Durum, Scott</creatorcontrib><creatorcontrib>Axelrod, Julius</creatorcontrib><title>Interleukin 1 Induces β-Endorphin Secretion via Fos and Jun in AtT-20 Pituitary Cells</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates β-endorphin release and potentiates the effects of secretagogues in AtT-20 cells, a mouse anterior pituitary cell line. Treatment of AtT-20 cells with IL-1 induced a transient and early stimulation of mRNA expression by both immediate-early protooncogenes Fos and Jun (mouse c-fos and c-jun). The effect appeared within 30 min, and returned to basal levels after 2 hr. Desensitization of protein kinase C by phorbol ester pretreatment had no effect on the ability of IL-1 to induce Fos and Jun mRNA expression. Somatostatin, an inhibitor of cAMP and β-endorphin secretion, did not reduce the IL-1 effect on Fos and Jun mRNA expression. Addition to AtT-20 cells of antisense oligonucleotides to Fos and Jun abolished the secretion induced by IL-1. These results indicate that immediate-early signals Fos and Jun are involved in IL-1-induced β-endorphin secretion in AtT-20 cells.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>beta-Endorphin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cells</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Interleukin-1 - pharmacology</subject><subject>Interleukins</subject><subject>Messenger RNA</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotide Probes</subject><subject>Oligonucleotides</subject><subject>Phorbol esters</subject><subject>Pituitary Gland, Anterior</subject><subject>Protein hormones. Growth factors. Cytokines</subject><subject>Protein Kinase C - metabolism</subject><subject>Protein-Tyrosine Kinases - genetics</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins c-fos</subject><subject>Proto-Oncogene Proteins c-jun</subject><subject>Proto-Oncogenes - drug effects</subject><subject>RNA</subject><subject>Secretion</subject><subject>Somatostatin - pharmacology</subject><subject>T lymphocytes</subject><subject>Transcription Factors - genetics</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS1EVULKmg0gb6CrSf0zHtsSmypqIagSlYjYWh6Ph7pM7GB7KngtHoRnwqOkfxtYXcnnu_ee6wPAS4wWGHF6svU6LQRfELTgguMnYIaRxFVTS_QUzBAivBI1qZ-B5yldI4QkE-gQHGLJBcXNDHxd-WzjYMfvzkMMV74bjU3wz-_qzHchbq_K8xdros0ueHjjNDwPCWrfwU-jh0U8zeuKIHjp8uiyjr_g0g5DOgIHvR6SfbGvc7A-P1svP1YXnz-slqcXlWGE5or2vWQtxQTZhnBqmpYLIqzFTKMOW93wVgojCWkxZy23tG4lNg2mBLOu6-kcvN-N3Y7txnbG-hz1oLbRbYoVFbRTjxXvrtS3cKNYLYqBOXi3b4_hx2hTVhuXTPGvvQ1jUgKVz6RC_hfEjDMpcVPAkx1oYkgp2v7OC0ZqCkxNgSnBFUFqCqx0vH54wj2_S6job_e6TkYPfdTeuPQAYzVv-MS92XPTglv50aLjfwKqH4ch25-5kK925HXKId6hhDJWU0b_ApbVwEE</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>Fagarasan, Mirela O.</creator><creator>Aiello, Francesca</creator><creator>Muegge, Katherin</creator><creator>Durum, Scott</creator><creator>Axelrod, Julius</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19901001</creationdate><title>Interleukin 1 Induces β-Endorphin Secretion via Fos and Jun in AtT-20 Pituitary Cells</title><author>Fagarasan, Mirela O. ; Aiello, Francesca ; Muegge, Katherin ; Durum, Scott ; Axelrod, Julius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-3ff95b3120e6273c6b7828ee15a0d1ea67b98c922b175b7e34b91c613215ddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>beta-Endorphin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cells</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Interleukin-1 - pharmacology</topic><topic>Interleukins</topic><topic>Messenger RNA</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotide Probes</topic><topic>Oligonucleotides</topic><topic>Phorbol esters</topic><topic>Pituitary Gland, Anterior</topic><topic>Protein hormones. Growth factors. Cytokines</topic><topic>Protein Kinase C - metabolism</topic><topic>Protein-Tyrosine Kinases - genetics</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins c-fos</topic><topic>Proto-Oncogene Proteins c-jun</topic><topic>Proto-Oncogenes - drug effects</topic><topic>RNA</topic><topic>Secretion</topic><topic>Somatostatin - pharmacology</topic><topic>T lymphocytes</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fagarasan, Mirela O.</creatorcontrib><creatorcontrib>Aiello, Francesca</creatorcontrib><creatorcontrib>Muegge, Katherin</creatorcontrib><creatorcontrib>Durum, Scott</creatorcontrib><creatorcontrib>Axelrod, Julius</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fagarasan, Mirela O.</au><au>Aiello, Francesca</au><au>Muegge, Katherin</au><au>Durum, Scott</au><au>Axelrod, Julius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin 1 Induces β-Endorphin Secretion via Fos and Jun in AtT-20 Pituitary Cells</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1990-10-01</date><risdate>1990</risdate><volume>87</volume><issue>20</issue><spage>7871</spage><epage>7874</epage><pages>7871-7874</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates β-endorphin release and potentiates the effects of secretagogues in AtT-20 cells, a mouse anterior pituitary cell line. Treatment of AtT-20 cells with IL-1 induced a transient and early stimulation of mRNA expression by both immediate-early protooncogenes Fos and Jun (mouse c-fos and c-jun). The effect appeared within 30 min, and returned to basal levels after 2 hr. Desensitization of protein kinase C by phorbol ester pretreatment had no effect on the ability of IL-1 to induce Fos and Jun mRNA expression. Somatostatin, an inhibitor of cAMP and β-endorphin secretion, did not reduce the IL-1 effect on Fos and Jun mRNA expression. Addition to AtT-20 cells of antisense oligonucleotides to Fos and Jun abolished the secretion induced by IL-1. These results indicate that immediate-early signals Fos and Jun are involved in IL-1-induced β-endorphin secretion in AtT-20 cells.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>1978316</pmid><doi>10.1073/pnas.87.20.7871</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (20), p.7871-7874 |
| issn | 0027-8424 1091-6490 |
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| subjects | Analytical, structural and metabolic biochemistry Animals Base Sequence beta-Endorphin - metabolism Biological and medical sciences Cell Line Cell lines Cells DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Genes Interleukin-1 - pharmacology Interleukins Messenger RNA Mice Molecular Sequence Data Oligonucleotide Probes Oligonucleotides Phorbol esters Pituitary Gland, Anterior Protein hormones. Growth factors. Cytokines Protein Kinase C - metabolism Protein-Tyrosine Kinases - genetics Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-jun Proto-Oncogenes - drug effects RNA Secretion Somatostatin - pharmacology T lymphocytes Transcription Factors - genetics |
| title | Interleukin 1 Induces β-Endorphin Secretion via Fos and Jun in AtT-20 Pituitary Cells |
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