Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis

Isoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose...

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Veröffentlicht in:	Journal of the Association of Physicians of India 2009-01, Vol.57, p.70
Hauptverfasser:	Gokhale, Yojana A, Vaidya, Meghna S, Mehta, A D, Rathod, N N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - chemically induced Acidosis - diagnosis Acidosis - drug therapy Adult Antitubercular Agents - adverse effects Bicarbonates - administration & dosage Bicarbonates - therapeutic use Buffers Diuretics, Osmotic - therapeutic use Female Humans Isoniazid - adverse effects Mannitol - administration & dosage Mannitol - therapeutic use Pyridoxine - administration & dosage Pyridoxine - therapeutic use Status Epilepticus - chemically induced Status Epilepticus - diagnosis Status Epilepticus - drug therapy Vitamin B Complex - administration & dosage Vitamin B Complex - therapeutic use
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