Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects

CB(1) cannabinoid (CB(1)) receptor agonists and N-Methyl-d-Aspartate (NMDA) receptor antagonists attenuate the development of morphine antinociceptive tolerance. The present study used dose-addition analysis to evaluate CB(1)/NMDA receptor interactions on this endpoint. Chronic morphine administrati...

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Veröffentlicht in:	Neuropharmacology 2010-02, Vol.58 (2), p.544
Hauptverfasser:	Fischer, Bradford D, Ward, Sara J, Henry, Fredrick E, Dykstra, Linda A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - administration & dosage Analgesics - pharmacology Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Cyclohexanols - administration & dosage Cyclohexanols - pharmacology Dose-Response Relationship, Drug Drug Interactions Drug Therapy, Combination Drug Tolerance Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Hot Temperature Isoquinolines - administration & dosage Isoquinolines - pharmacology Male Mice Mice, Inbred C57BL Morphine - administration & dosage Morphine - pharmacology Pain - drug therapy Pain - metabolism Pain Measurement Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism
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