The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances

Serotonin receptor (5-HTR) agonists that target 5-HT4(a)R and 5-HT1AR can reverse μ-opioid receptor (μ-OR)-evoked respiratory depression. Here, we have tested whether such rescuing by serotonin agonists also applies to the cardiovascular system. In working heart-brainstem preparations in situ, we ha...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2009-09, Vol.364 (1529), p.2611-2623
Hauptverfasser:	Dutschmann, M., Waki, H., Manzke, T., Simms, A. E., Pickering, A. E., Richter, D. W., Paton, J. F. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Agonists Analgesics, Opioid - metabolism Aniline Compounds - pharmacology Animals Apneusis Apnoea Awake Blood pressure Blood Pressure - drug effects Bradycardia Brain stem Brain Stem - physiology Breathing Cardio-Sympathetic Coupling Cardiovascular Control Cardiovascular Physiological Phenomena - drug effects Diaphragm - drug effects Diaphragm - physiology Electromyography Fentanyl - pharmacology Heart - physiology Heart Rate - drug effects Histocytochemistry in vivo awake Neural Control Of Breathing Neurons Opioid analgesics Phrenic Nerve - drug effects Piperidines - pharmacology Rats Receptors Receptors, Opioid, mu - agonists Receptors, Opioid, mu - metabolism Respiratory insufficiency Review Serotonin Receptor Agonists - pharmacology Serotonin receptors Telemetry Vascular Resistance - drug effects
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