HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells

Evidence points towards a pivotal role for cyclooxygenase (COX)-2 in promoting colorectal tumorigenesis through increasing prostaglandin E(2) (PGE(2)) levels. PGE(2) signalling is closely associated with the survival, proliferation and invasion of colorectal cancer cells. Recently, a reduction in PG...

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Veröffentlicht in:	Carcinogenesis (New York) 2009-10, Vol.30 (10), p.1796
Hauptverfasser:	Moore, Amy E, Greenhough, Alexander, Roberts, Heather R, Hicks, Diane J, Patsos, Helena A, Williams, Ann C, Paraskeva, Christos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Animals Cell Line, Tumor Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - therapy Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Dinoprostone - biosynthesis Down-Regulation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Hydroxyprostaglandin Dehydrogenases - genetics Mice Mice, Nude Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-met Receptors, Growth Factor - physiology Signal Transduction Up-Regulation
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