Mutant p53 rescue and modulation of p53 redox state

The p53 tumor suppressor is a key regulator of cell growth and survival upon various forms of cellular stress. p53 is a redox-regulated transcription factor that binds specifically to DNA and activates transcription of target genes. The core domain of p53 holds a zinc atom that protects p53 from oxi...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2009-08, Vol.8 (16), p.2509-2517
Hauptverfasser:	Bykov, Vladimir J.N., Lambert, Jeremy M.R., Hainaut, Pierre, Wiman, Klas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Apoptosis - physiology Binding Biology Bioscience Calcium Cancer Cell Cycle Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Humans Landes Medicin och hälsovetenskap Models, Biological Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - therapy Organogenesis Oxidation-Reduction Proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology
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