Immunotoxicity profile of natalizumab

Natalizumab is a monoclonal antibody to human α4 integrin indicated for treatment of multiple sclerosis and Crohn's disease that prevents extravasation of leukocytes into surrounding tissues and their involvement in inflammation. Because α4 integrins and their receptors are involved in hematopo...

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Veröffentlicht in:	Journal of immunotoxicology 2009-06, Vol.6 (2), p.115-129
Hauptverfasser:	Wehner, Nancy G., Gasper, Carolyn, Shopp, George, Nelson, Joyce, Draper, Ken, Parker, Suezanne, Clarke, Janet
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antibody Formation - drug effects Antigens, CD - metabolism B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Cell Movement - drug effects Cell Proliferation - drug effects Clinical Trials as Topic Crohn Disease - immunology Crohn Disease - therapy Cytokines - secretion Cytotoxicity, Immunologic - drug effects Hematopoiesis - drug effects Humans immune function Immunotherapy Integrin alpha4 - immunology K562 Cells Leukocyte Count Lymphocyte Activation - drug effects Macaca fascicularis Macaca mulatta monoclonal antibody Multiple Sclerosis - immunology Multiple Sclerosis - therapy Natalizumab Organ Size Stem Cells - drug effects Stem Cells - immunology Stem Cells - metabolism Stem Cells - pathology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology α4 integrin
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