Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo

Natural killer (NK) cells are lymphocytes of the innate immune system able to recognize and kill tumors lacking self-MHC class I molecules. This "missing-self" recognition is mediated by the lack of engagement of MHC class I-specific inhibitory NK cell receptors that include the killer cel...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-08, Vol.106 (31), p.12879-12884
Hauptverfasser:	Sola, Caroline, André, Pascale, Lemmers, Céline, Fuseri, Nicolas, Bonnafous, Cécile, Bléry, Mathieu, Wagtmann, Nicolai R, Romagné, François, Vivier, Eric, Ugolini, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal Antibodies, Monoclonal - therapeutic use Biological Sciences Blood Cancer Cell Line Cells HLA antigens HLA-C Antigens HLA-C Antigens - physiology Humans Immunity, Innate Immunology Killer Cells, Natural Killer Cells, Natural - immunology Life Sciences Ligands Lymphocytes Mice Mice, Inbred C57BL Molecules Monoclonal antibodies Natural killer cells Neoplasms, Experimental Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Receptors Receptors, KIR2DL3 Receptors, KIR2DL3 - immunology Receptors, KIR2DL3 - physiology Rodents Self Tolerance Splenocytes T lymphocytes Tumors
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