Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

Adjustable control of therapeutic transgenes in engineered cell implants after transdermal and topical delivery of nontoxic trigger molecules would increase convenience, patient compliance, and elimination of hepatic first-pass effect in future therapies. Pseudomonas putida DOT-T1E has evolved the f...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-06, Vol.106 (26), p.10638-10643
Hauptverfasser:	Gitzinger, Marc, Kemmer, Christian, El-Baba, Marie Daoud, Weber, Wilfried, Fussenegger, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Bacteria Biological Sciences Cell culture techniques Cell Line Cell Line, Tumor Cell lines Cell Transplantation - methods Cells Cercopithecus aethiops CHO Cells COS Cells Cricetinae Cricetulus Dermatologic Agents - pharmacology Dose-Response Relationship, Drug Flavonoids Flavonoids - pharmacology Gene expression Gene expression regulation Gene Expression Regulation - drug effects Genes Genetic Vectors - genetics Humans Kidney cells Malus Malus - metabolism Metabolism Metabolites Mice NIH 3T3 Cells Operon - genetics Phloretin - pharmacology Proteins Pseudomonas putida Pseudomonas putida - genetics Response Elements - genetics Skin Transdermal application Transfection Transgenes Transgenes - genetics
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