Improvement of glucose intolerance by combination of pravastatin and olmesartan in type II diabetic KK-A(y) mice

The effects of the coadministration of pravastatin and an angiotensin type 1 (AT(1)) receptor blocker, olmesartan, on glucose intolerance were examined using type II diabetic mice. Male KK-A(y) mice (8 weeks of age) were treated with pravastatin and/or olmesartan for 2 weeks. An oral glucose toleran...

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Veröffentlicht in:	Hypertension research 2009-08, Vol.32 (8), p.706
Hauptverfasser:	Kanno, Harumi, Iwai, Masaru, Inaba, Shinji, Senba, Izumi, Nakaoka, Hirotomo, Sone, Hisako, Mogi, Masaki, Horiuchi, Masatsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - therapeutic use Animals Antimetabolites Antioxidants - pharmacology Blood Glucose - metabolism Cyclic N-Oxides - pharmacology Deoxyglucose Diabetes Mellitus, Type 2 - complications Drug Therapy, Combination Glucose Intolerance - drug therapy Glucose Intolerance - genetics Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Imidazoles - therapeutic use Insulin - blood Male Mice Mice, Inbred C57BL Mice, Inbred Strains Oxidative Stress - drug effects Pravastatin - therapeutic use Spin Labels Tetrazoles - therapeutic use
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