Methylation Analysis of BRCA1, RASSF1, GSTP1 and EPHB2 Promoters in Prostate Biopsies According to Different Degrees of Malignancy
Prostate cancer is the most common cancer among men and the second leading cause of cancer-related deaths in the United States. CpG island methylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. Its role was investigated at multiple gene sites during prost...
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| Veröffentlicht in: | In vivo (Athens) 2009-05, Vol.23 (3), p.387 |
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| container_title | In vivo (Athens) |
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| creator | Rabiau, Nadège Thiam, Mohamed Oury Satih, Samir Guy, Laurent Kemeny, Jean-Louis Boiteux, Jean-Paul Fontana, Luc Bignon, Yves-Jean Bernard-Gallon, Dominique |
| description | Prostate cancer is the most common cancer among men and the second leading cause of cancer-related deaths in the United States.
CpG island methylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. Its role was
investigated at multiple gene sites during prostate carcinogenesis. Methylation-specific polymerase chain reaction (MS-PCR)
was used to analyze 4 interest gene promoter status in 12 patients with adenocarcinoma, 7 patients with prostate intraepithelial
neoplasia, 3 patients with peritumor tissues and 15 healthy patients, so a total of 37 prostate biopsy samples constituted
the cohort of the study. Despite the biopsy histology, the results have confirmed that BRCA1, RASSF1, GSTP1 and EPHB2 promoter
methylation was found in each sample, except two. |
| format | Article |
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CpG island methylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. Its role was
investigated at multiple gene sites during prostate carcinogenesis. Methylation-specific polymerase chain reaction (MS-PCR)
was used to analyze 4 interest gene promoter status in 12 patients with adenocarcinoma, 7 patients with prostate intraepithelial
neoplasia, 3 patients with peritumor tissues and 15 healthy patients, so a total of 37 prostate biopsy samples constituted
the cohort of the study. Despite the biopsy histology, the results have confirmed that BRCA1, RASSF1, GSTP1 and EPHB2 promoter
methylation was found in each sample, except two.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 19454503</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Base Sequence ; DNA Methylation ; DNA Primers ; Genes, BRCA1 ; Glutathione S-Transferase pi - genetics ; Humans ; Male ; Polymerase Chain Reaction ; Promoter Regions, Genetic ; Prostatic Neoplasms - classification ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Receptor, EphB2 - genetics ; Tumor Suppressor Proteins - genetics</subject><ispartof>In vivo (Athens), 2009-05, Vol.23 (3), p.387</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19454503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabiau, Nadège</creatorcontrib><creatorcontrib>Thiam, Mohamed Oury</creatorcontrib><creatorcontrib>Satih, Samir</creatorcontrib><creatorcontrib>Guy, Laurent</creatorcontrib><creatorcontrib>Kemeny, Jean-Louis</creatorcontrib><creatorcontrib>Boiteux, Jean-Paul</creatorcontrib><creatorcontrib>Fontana, Luc</creatorcontrib><creatorcontrib>Bignon, Yves-Jean</creatorcontrib><creatorcontrib>Bernard-Gallon, Dominique</creatorcontrib><title>Methylation Analysis of BRCA1, RASSF1, GSTP1 and EPHB2 Promoters in Prostate Biopsies According to Different Degrees of Malignancy</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Prostate cancer is the most common cancer among men and the second leading cause of cancer-related deaths in the United States.
CpG island methylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. Its role was
investigated at multiple gene sites during prostate carcinogenesis. Methylation-specific polymerase chain reaction (MS-PCR)
was used to analyze 4 interest gene promoter status in 12 patients with adenocarcinoma, 7 patients with prostate intraepithelial
neoplasia, 3 patients with peritumor tissues and 15 healthy patients, so a total of 37 prostate biopsy samples constituted
the cohort of the study. Despite the biopsy histology, the results have confirmed that BRCA1, RASSF1, GSTP1 and EPHB2 promoter
methylation was found in each sample, except two.</description><subject>Base Sequence</subject><subject>DNA Methylation</subject><subject>DNA Primers</subject><subject>Genes, BRCA1</subject><subject>Glutathione S-Transferase pi - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Polymerase Chain Reaction</subject><subject>Promoter Regions, Genetic</subject><subject>Prostatic Neoplasms - classification</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Receptor, EphB2 - genetics</subject><subject>Tumor Suppressor Proteins - genetics</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LwzAAhoMobk7_guTg0UI-2iU9dt_ChmOb4K2kTdJGunQkUenVX251ynt4eOHhPbwXYIhZiiOWxOklGCKS8Ign-HUAbrx_Q2jMECLXYIDTOIkTRIfga6NC3TUimNbCzIqm88bDVsPJbprhR7jL9vtFz-X-sMVQWAnn29WEwK1rj21QzkNjf4oPIig4Me3JG-VhVpatk8ZWMLRwZrRWTtkAZ6pySv3ub0RjKits2d2CKy0ar-7-OAIvi_lhuorWz8unabaOakJ5iDjDXBLOCl5qSgVTskSYjDETUmqpcFFIzeOU07hMiZZcF4jEhSjJWFBWpAkdgfvz7um9OCqZn5w5Ctfl_2f0wsNZqE1Vfxqncn8UTdPrNDcfhOZ9OKPfOaFofA</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Rabiau, Nadège</creator><creator>Thiam, Mohamed Oury</creator><creator>Satih, Samir</creator><creator>Guy, Laurent</creator><creator>Kemeny, Jean-Louis</creator><creator>Boiteux, Jean-Paul</creator><creator>Fontana, Luc</creator><creator>Bignon, Yves-Jean</creator><creator>Bernard-Gallon, Dominique</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20090501</creationdate><title>Methylation Analysis of BRCA1, RASSF1, GSTP1 and EPHB2 Promoters in Prostate Biopsies According to Different Degrees of Malignancy</title><author>Rabiau, Nadège ; Thiam, Mohamed Oury ; Satih, Samir ; Guy, Laurent ; Kemeny, Jean-Louis ; Boiteux, Jean-Paul ; Fontana, Luc ; Bignon, Yves-Jean ; Bernard-Gallon, Dominique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-8718d287b8cf33a7edc012617addfde1bbdf849834c92fd8fb024bac26a37b953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Base Sequence</topic><topic>DNA Methylation</topic><topic>DNA Primers</topic><topic>Genes, BRCA1</topic><topic>Glutathione S-Transferase pi - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Polymerase Chain Reaction</topic><topic>Promoter Regions, Genetic</topic><topic>Prostatic Neoplasms - classification</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Receptor, EphB2 - genetics</topic><topic>Tumor Suppressor Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rabiau, Nadège</creatorcontrib><creatorcontrib>Thiam, Mohamed Oury</creatorcontrib><creatorcontrib>Satih, Samir</creatorcontrib><creatorcontrib>Guy, Laurent</creatorcontrib><creatorcontrib>Kemeny, Jean-Louis</creatorcontrib><creatorcontrib>Boiteux, Jean-Paul</creatorcontrib><creatorcontrib>Fontana, Luc</creatorcontrib><creatorcontrib>Bignon, Yves-Jean</creatorcontrib><creatorcontrib>Bernard-Gallon, Dominique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabiau, Nadège</au><au>Thiam, Mohamed Oury</au><au>Satih, Samir</au><au>Guy, Laurent</au><au>Kemeny, Jean-Louis</au><au>Boiteux, Jean-Paul</au><au>Fontana, Luc</au><au>Bignon, Yves-Jean</au><au>Bernard-Gallon, Dominique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylation Analysis of BRCA1, RASSF1, GSTP1 and EPHB2 Promoters in Prostate Biopsies According to Different Degrees of Malignancy</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>23</volume><issue>3</issue><spage>387</spage><pages>387-</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Prostate cancer is the most common cancer among men and the second leading cause of cancer-related deaths in the United States.
CpG island methylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. Its role was
investigated at multiple gene sites during prostate carcinogenesis. Methylation-specific polymerase chain reaction (MS-PCR)
was used to analyze 4 interest gene promoter status in 12 patients with adenocarcinoma, 7 patients with prostate intraepithelial
neoplasia, 3 patients with peritumor tissues and 15 healthy patients, so a total of 37 prostate biopsy samples constituted
the cohort of the study. Despite the biopsy histology, the results have confirmed that BRCA1, RASSF1, GSTP1 and EPHB2 promoter
methylation was found in each sample, except two.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>19454503</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0258-851X |
| ispartof | In vivo (Athens), 2009-05, Vol.23 (3), p.387 |
| issn | 0258-851X 1791-7549 |
| language | eng |
| recordid | cdi_pubmed_primary_19454503 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Base Sequence DNA Methylation DNA Primers Genes, BRCA1 Glutathione S-Transferase pi - genetics Humans Male Polymerase Chain Reaction Promoter Regions, Genetic Prostatic Neoplasms - classification Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Receptor, EphB2 - genetics Tumor Suppressor Proteins - genetics |
| title | Methylation Analysis of BRCA1, RASSF1, GSTP1 and EPHB2 Promoters in Prostate Biopsies According to Different Degrees of Malignancy |
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