Effects of low-dose mizoribine pulse therapy in combination with methotrexate in rheumatoid arthritis patients with an insufficient response to methotrexate

The aim was to determine the efficacy of low-dose intermittent pulse administration of mizoribine (MZR), a purine synthesis inhibitor, in combination with methotrexate (MTX) to control the symptoms of rheumatoid arthritis (RA) in patients with an insufficient clinical response to MTX alone. Twenty-s...

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Veröffentlicht in:	Modern rheumatology 2009, Vol.19 (4), p.395-400
Hauptverfasser:	Kasama, Tsuyoshi, Wakabayashi, Kuninobu, Odai, Tsuyoshi, Isozaki, Takeo, Matsunawa, Mizuho, Yajima, Nobuyuki, Miwa, Yusuke, Negishi, Masao, Ide, Hirotsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - physiopathology C-Reactive Protein - analysis Dose-Response Relationship, Drug Drug Resistance - drug effects Drug therapy Drug Therapy, Combination Female Health Status Humans Immune system Joints - drug effects Joints - physiopathology Male Matrix Metalloproteinase 3 - blood Medicine Medicine & Public Health Methotrexate - therapeutic use Middle Aged Original Article Orthopedics Prospective Studies Rheumatoid arthritis Rheumatology Ribonucleosides - therapeutic use Severity of Illness Index Surveys and Questionnaires
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